Amo-Ochoa Pilar, Castillo Oscar, Sanz Miguel Pablo J, Zamora Félix
Departamento de Tecnología Industrial, Universidad Alfonso X El Sabio, 28691 Villanueva de la Cañada, Madrid, Spain.
J Inorg Biochem. 2008 Feb;102(2):203-8. doi: 10.1016/j.jinorgbio.2007.07.036. Epub 2007 Aug 7.
Synthesis and crystal structure of two Zn(II) dimer complexes with 1-methylcytosine (1-MeC) are reported. In complex [Zn(2)Cl(4)(mu-1-MeC-O2,N3)(2)] (1), two 1-MeC ligands are bridging two ZnCl(2) moieties. In [Zn(2)(1-MeC-N3)(4)(mu-SO(4))(2)].2H(2)O (2), the sulfates act as bridging ligands and 1-MeC are linked via N3 to Zn(II) as terminal ligands. Both complexes represent the first examples of Zn(II)-pyrimidine dimers. The potential biological significance of 1 and 2 is discussed.
报道了两种含1-甲基胞嘧啶（1-MeC）的锌（II）二聚体配合物的合成及晶体结构。在配合物[Zn(2)Cl(4)(μ-1-MeC-O2,N3)(2)]（1）中，两个1-MeC配体桥连两个ZnCl(2)部分。在[Zn(2)(1-MeC-N3)(4)(μ-SO(4))(2)].2H(2)O（2）中，硫酸根作为桥连配体，1-MeC通过N3作为末端配体与锌（II）相连。两种配合物均为锌（II）-嘧啶二聚体的首例。讨论了1和2潜在的生物学意义。
