Khalifa M, Kaabia N, Bahri F, Ben Jazia E, Bouajina E, Omezzine Letaief A
Department of Internal Medicine and Infectious Diseases, University Hospital Center Farhat-Hached, 4000 Sousse, Tunisia.
Med Mal Infect. 2007 Dec;37(12):792-5. doi: 10.1016/j.medmal.2007.07.003. Epub 2007 Sep 17.
Infections are common in patients with systemic lupus erythematosus (SLE) throughout the course of their disease and remain a source of mortality. The aim of this study was to determine the prevalence of infections, to describe their nature, and analyze their risk factors in adults with SLE.
We performed a descriptive study, at the Farhat-Hached Hospital in Sousse, and retrospectively analyzed the charts of 75 patients with SLE seen between 1990 and 2004. The group of patients with documented infections was compared to a control group. A logistic regression analysis was performed to determine risk factors associated with infection.
Our study included 64 women and 11 men (median age of 31.4 years). Forty-three patients (57.5%) had 82 infectious episodes: 23 patients had at least two infectious episodes. Most infections were community acquired, and 80% were severe. The most common infections involved the urinary tract (28%), the skin and soft tissue (26.8%), and the respiratory tract (18.3%). Documented pathogens were: 45 common bacteria, 11 Candida albicans and four Mycobacterium tuberculosis. Localized herpes zoster was noted in three cases. Factors associated with infection, found in univariate analysis, were renal involvement, serum albumin lower than 25 g/l, and corticosteroids treatment. Only corticosteroids therapy remained statistically significant after multivariate analysis.
感染在系统性红斑狼疮（SLE）患者病程中很常见，并且仍是死亡原因之一。本研究旨在确定感染的患病率，描述其性质，并分析成年SLE患者的感染危险因素。
我们在苏塞的法哈特-哈谢德医院进行了一项描述性研究，回顾性分析了1990年至2004年间诊治的75例SLE患者的病历。将有记录感染的患者组与对照组进行比较。进行逻辑回归分析以确定与感染相关的危险因素。
我们的研究纳入了64名女性和11名男性（中位年龄31.4岁）。43例患者（57.5%）发生了82次感染发作：23例患者至少有两次感染发作。大多数感染为社区获得性，80%为严重感染。最常见的感染累及泌尿系统（28%）、皮肤和软组织（26.8%）以及呼吸道（18.3%）。记录到的病原体有：45种常见细菌、11株白色念珠菌和4株结核分枝杆菌。3例患者出现局部带状疱疹。单因素分析中发现的与感染相关的因素有肾脏受累、血清白蛋白低于25 g/l以及皮质类固醇治疗。多因素分析后仅皮质类固醇治疗仍具有统计学意义。
