甲氟喹与三日口服奎宁-克林霉素治疗非复杂性输入性恶性疟的比较
Mefloquine versus 3-day oral quinine-clindamycin in uncomplicated imported falciparum malaria.
作者信息
Ranque Stéphane, Parola Philippe, Adehossi Eric, Brouqui Philippe, Delmont Jean
机构信息
Laboratoire de Parasitologie et Mycologie, IFR 48, Faculté de Médecine, 27 Bd. Jean Moulin, 13385 Marseille Cedex 5, France.
出版信息
Travel Med Infect Dis. 2007 Sep;5(5):306-9. doi: 10.1016/j.tmaid.2007.07.001. Epub 2007 Aug 20.
In this open randomized trial comparing 3-day oral quinine-clindamycin versus standard mefloquine regimen for uncomplicated imported falciparum malaria, mefloquine treatment was associated with a higher risk of discontinuation of the treatment (RR=1.8, 95% CI [1.1-2.8]) related to mainly mild gastrointestinal adverse drug events. The poor tolerability of mefloquine sets a question mark against its use in outpatients.
在这项开放性随机试验中，比较了3日口服奎宁-克林霉素与标准甲氟喹方案治疗非复杂性输入性恶性疟的疗效，结果显示，甲氟喹治疗因主要为轻度胃肠道药物不良事件而导致治疗中断的风险更高（相对危险度=1.8，95%置信区间[1.1 - 2.8]）。甲氟喹耐受性差，这对其在门诊患者中的使用提出了质疑。
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