变应性接触性皮炎的范式转变：固有免疫的作用。
Shifting Paradigms in Allergic Contact Dermatitis: The Role of Innate Immunity.
机构信息
Duke University Medical Center, Department of Dermatology, Duke University Medical Center, DUMC 3135, Durham, North Carolina, USA.
Duke University Medical Center, Department of Dermatology, Duke University Medical Center, DUMC 3135, Durham, North Carolina, USA.
出版信息
J Invest Dermatol. 2020 Jan;140(1):21-28. doi: 10.1016/j.jid.2019.03.1133. Epub 2019 May 14.
Abstract
The role of the innate immune system in allergic contact dermatitis (ACD) has traditionally been confined to the initial antigen sensitization phase. However, more recent findings have shown the role of innate immunity in additional aspects of ACD, including the effector phase of the classic type IV hypersensitivity reaction. As a result, the precise immunologic mechanisms mediating ACD are more complex than previously believed. The aim of this review is to provide insight into recent advances in understanding the role of the innate immune system in the pathogenesis of ACD, including novel mechanistic roles for macrophages, innate lymphoid cells, natural killer cells, innate γδ T cells, and other signaling molecules. These insights provide new opportunities for therapeutic intervention in ACD.
摘要
固有免疫系统在变应性接触性皮炎（ACD）中的作用传统上仅限于初始抗原致敏阶段。然而，最近的研究结果表明固有免疫在 ACD 的其他方面也发挥了作用，包括经典 IV 型超敏反应的效应阶段。因此，介导 ACD 的精确免疫机制比以前认为的更为复杂。本综述的目的是深入了解固有免疫系统在 ACD 发病机制中的作用的最新进展，包括巨噬细胞、固有淋巴细胞、自然杀伤细胞、固有 γδ T 细胞和其他信号分子的新的机制作用。这些见解为 ACD 的治疗干预提供了新的机会。
相似文献
1
Shifting Paradigms in Allergic Contact Dermatitis: The Role of Innate Immunity.变应性接触性皮炎的范式转变：固有免疫的作用。
J Invest Dermatol. 2020 Jan;140(1):21-28. doi: 10.1016/j.jid.2019.03.1133. Epub 2019 May 14.
2
Intricate Relationship Between Adaptive and Innate Immune System in Allergic Contact Dermatitis.变应性接触性皮炎中适应性免疫系统和固有免疫系统的复杂关系。
Yale J Biol Med. 2020 Dec 29;93(5):699-709. eCollection 2020 Dec.
3
Immunology of allergic contact dermatitis.过敏性接触性皮炎的免疫学
Acta Dermatovenerol Croat. 2011;19(1):51-68.
4
Innate and adaptive immune responses in contact dermatitis: analogy with infections.接触性皮炎中的先天性和适应性免疫反应：与感染的类比。
G Ital Dermatol Venereol. 2009 Apr;144(2):173-85.
5
Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis.过敏性接触性皮炎中涉及的固有免疫以及效应和调节机制。
An Bras Dermatol. 2018 Mar;93(2):242-250. doi: 10.1590/abd1806-4841.20186340.
6
Allergic contact dermatitis.过敏性接触性皮炎
Curr Dir Autoimmun. 2008;10:1-26. doi: 10.1159/000131410.
7
Novel concept of iSALT (inducible skin-associated lymphoid tissue) in the elicitation of allergic contact dermatitis.诱导性皮肤相关淋巴组织（iSALT）在过敏性接触性皮炎诱发中的新概念。
Proc Jpn Acad Ser B Phys Biol Sci. 2016;92(1):20-8. doi: 10.2183/pjab.92.20.
8
9
Chemokine Signaling in Allergic Contact Dermatitis: Toward Targeted Therapies.趋化因子信号在变应性接触性皮炎中的作用：靶向治疗策略。
Dermatitis. 2018 Jul/Aug;29(4):179-186. doi: 10.1097/DER.0000000000000391.
10
Role of Innate Immunity in Allergic Contact Dermatitis: An Update.固有免疫在变应性接触性皮炎中的作用：更新。
Int J Mol Sci. 2023 Aug 19;24(16):12975. doi: 10.3390/ijms241612975.
引用本文的文献
1
Weak Sensitizers May Be Associated with CD80 Polymorphisms: Implications for Systemic Contact Dermatitis.弱致敏原可能与CD80基因多态性相关：对系统性接触性皮炎的影响
JID Innov. 2025 May 9;5(4):100382. doi: 10.1016/j.xjidi.2025.100382. eCollection 2025 Jul.
2
Resolution of Chronic Inflammation, Restoration of Epigenetic Disturbances and Correction of Dysbiosis as an Adjunctive Approach to the Treatment of Atopic Dermatitis.慢性炎症的消退、表观遗传紊乱的恢复和微生态失调的纠正作为特应性皮炎治疗的辅助方法。
Cells. 2024 Nov 18;13(22):1899. doi: 10.3390/cells13221899.
3
The Involvement of Cysteine-X-Cysteine Motif Chemokine Receptors in Skin Homeostasis and the Pathogenesis of Allergic Contact Dermatitis and Psoriasis.半胱氨酸-X-半胱氨酸基趋化因子受体在皮肤稳态和过敏性接触性皮炎及银屑病发病机制中的作用。
Int J Mol Sci. 2024 Jan 13;25(2):1005. doi: 10.3390/ijms25021005.
4
Immunomodulatory effects of nanoparticles on dendritic cells in a model of allergic contact dermatitis: importance of PD-L2 expression.纳米颗粒对变应性接触性皮炎模型中树突状细胞的免疫调节作用：PD-L2 表达的重要性。
Sci Rep. 2023 Sep 25;13(1):15992. doi: 10.1038/s41598-023-42797-5.
5
Role of Innate Immunity in Allergic Contact Dermatitis: An Update.固有免疫在变应性接触性皮炎中的作用：更新。
Int J Mol Sci. 2023 Aug 19;24(16):12975. doi: 10.3390/ijms241612975.
6
The junctional adhesion molecule-like protein (JAML) is important for the inflammatory response during contact hypersensitivity.连接黏附分子样蛋白（JAML）在接触性超敏反应期间的炎症反应中很重要。
Contact Dermatitis. 2023 Nov;89(5):323-334. doi: 10.1111/cod.14409. Epub 2023 Aug 24.
7
Immunomodulatory Effects of Nanoparticles on Dendritic Cells in a Model of Allergic Contact Dermatitis - Importance of PD-L2 Expression.纳米颗粒在过敏性接触性皮炎模型中对树突状细胞的免疫调节作用——PD-L2表达的重要性
Res Sq. 2023 Jul 12:rs.3.rs-3069059. doi: 10.21203/rs.3.rs-3069059/v1.
8
Diseases from the Spectrum of Dermatitis and Eczema: Can "Omics" Sciences Help with Better Systematics and More Accurate Differential Diagnosis?从皮炎和湿疹谱的疾病：“组学”科学能否帮助更好地分类和更准确的鉴别诊断？
Int J Mol Sci. 2023 Jun 21;24(13):10468. doi: 10.3390/ijms241310468.
9
MR1 deficiency enhances IL-17-mediated allergic contact dermatitis.MR1 缺乏增强了 IL-17 介导的过敏性接触性皮炎。
Front Immunol. 2023 Jun 20;14:1215478. doi: 10.3389/fimmu.2023.1215478. eCollection 2023.
10
Integrative metabolomics of plasma and PBMCs identifies distinctive metabolic signatures in Behçet's disease.血浆和 PBMCs 的整合代谢组学鉴定出 Behçet's 病的独特代谢特征。
Arthritis Res Ther. 2023 Jan 7;25(1):5. doi: 10.1186/s13075-022-02986-5.
本文引用的文献
1
Lack of Type 2 Innate Lymphoid Cells Promotes a Type I-Driven Enhanced Immune Response in Contact Hypersensitivity.缺乏 2 型先天淋巴细胞会促进接触性超敏反应中 I 型驱动的增强免疫应答。
J Invest Dermatol. 2018 Sep;138(9):1962-1972. doi: 10.1016/j.jid.2018.03.001. Epub 2018 Mar 9.
2
NF-κB signaling in inflammation.NF-κB 信号转导与炎症
Signal Transduct Target Ther. 2017;2:17023-. doi: 10.1038/sigtrans.2017.23. Epub 2017 Jul 14.
3
Macrophages: Their role, activation and polarization in pulmonary diseases.巨噬细胞：它们在肺部疾病中的作用、激活与极化
Immunobiology. 2018 Apr-May;223(4-5):383-396. doi: 10.1016/j.imbio.2017.11.001. Epub 2017 Nov 12.
4
The N-Acylethanolamine Acid Amidase Inhibitor ARN077 Suppresses Inflammation and Pruritus in a Mouse Model of Allergic Dermatitis.N-酰基乙醇胺酸酰胺酶抑制剂 ARN077 抑制变应性接触性皮炎小鼠模型的炎症和瘙痒。
J Invest Dermatol. 2018 Mar;138(3):562-569. doi: 10.1016/j.jid.2017.07.853. Epub 2017 Oct 18.
5
CD64: An Attractive Immunotherapeutic Target for M1-type Macrophage Mediated Chronic Inflammatory Diseases.CD64：M1型巨噬细胞介导的慢性炎症性疾病的一个有吸引力的免疫治疗靶点。
Biomedicines. 2017 Sep 12;5(3):56. doi: 10.3390/biomedicines5030056.
6
Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.单核细胞/巨噬细胞中的精氨酸酶1缺乏会上调诱导型一氧化氮合酶以促进皮肤接触性超敏反应。
J Immunol. 2017 Sep 1;199(5):1827-1834. doi: 10.4049/jimmunol.1700739. Epub 2017 Jul 26.
7
STAT6 Upregulation Promotes M2 Macrophage Polarization to Suppress Atherosclerosis.信号转导和转录激活因子6（STAT6）上调促进M2巨噬细胞极化以抑制动脉粥样硬化。
Med Sci Monit Basic Res. 2017 Jun 15;23:240-249. doi: 10.12659/msmbr.904014.
8
Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease.2型天然淋巴细胞可治疗和预防急性胃肠道移植物抗宿主病。
J Clin Invest. 2017 May 1;127(5):1813-1825. doi: 10.1172/JCI91816. Epub 2017 Apr 4.
9
NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells.自然杀伤细胞通过负向调节2型固有淋巴细胞减轻肺部炎症。
J Immunol. 2017 Apr 15;198(8):3336-3344. doi: 10.4049/jimmunol.1601830. Epub 2017 Mar 8.
10
Allergic Contact Dermatitis.变应性接触性皮炎
Immunol Allergy Clin North Am. 2017 Feb;37(1):141-152. doi: 10.1016/j.iac.2016.08.014.
Zotero 插件