Duke University Medical Center, Department of Dermatology, Duke University Medical Center, DUMC 3135, Durham, North Carolina, USA.
Duke University Medical Center, Department of Dermatology, Duke University Medical Center, DUMC 3135, Durham, North Carolina, USA.
J Invest Dermatol. 2020 Jan;140(1):21-28. doi: 10.1016/j.jid.2019.03.1133. Epub 2019 May 14.
The role of the innate immune system in allergic contact dermatitis (ACD) has traditionally been confined to the initial antigen sensitization phase. However, more recent findings have shown the role of innate immunity in additional aspects of ACD, including the effector phase of the classic type IV hypersensitivity reaction. As a result, the precise immunologic mechanisms mediating ACD are more complex than previously believed. The aim of this review is to provide insight into recent advances in understanding the role of the innate immune system in the pathogenesis of ACD, including novel mechanistic roles for macrophages, innate lymphoid cells, natural killer cells, innate γδ T cells, and other signaling molecules. These insights provide new opportunities for therapeutic intervention in ACD.
固有免疫系统在变应性接触性皮炎（ACD）中的作用传统上仅限于初始抗原致敏阶段。然而，最近的研究结果表明固有免疫在 ACD 的其他方面也发挥了作用，包括经典 IV 型超敏反应的效应阶段。因此，介导 ACD 的精确免疫机制比以前认为的更为复杂。本综述的目的是深入了解固有免疫系统在 ACD 发病机制中的作用的最新进展，包括巨噬细胞、固有淋巴细胞、自然杀伤细胞、固有 γδ T 细胞和其他信号分子的新的机制作用。这些见解为 ACD 的治疗干预提供了新的机会。
