Chen Lihui, Li Jie, Zhu Wu, Kuang Yehong, Liu Tao, Zhang Wei, Chen Xiang, Peng Cong
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
Front Microbiol. 2020 Dec 15;11:589726. doi: 10.3389/fmicb.2020.589726. eCollection 2020.
Psoriasis affects the health of myriad populations around the world. The pathogenesis is multifactorial, and the exact driving factor remains unclear. This condition arises from the interaction between hyperproliferative keratinocytes and infiltrating immune cells, with poor prognosis and high recurrence. Better clinical treatments remain to be explored. There is much evidence that alterations in the skin and intestinal microbiome play an important role in the pathogenesis of psoriasis, and restoration of the microbiome is a promising preventive and therapeutic strategy for psoriasis. Herein, we have reviewed recent studies on the psoriasis-related microbiome in an attempt to confidently identify the "core" microbiome of psoriasis patients, understand the role of microbiome in the pathogenesis of psoriasis, and explore new therapeutic strategies for psoriasis through microbial intervention.
银屑病影响着全球无数人群的健康。其发病机制是多因素的，确切的驱动因素仍不清楚。这种疾病源于过度增殖的角质形成细胞与浸润的免疫细胞之间的相互作用，预后较差且复发率高。更好的临床治疗方法仍有待探索。有大量证据表明，皮肤和肠道微生物群的改变在银屑病的发病机制中起重要作用，恢复微生物群是一种有前景的银屑病预防和治疗策略。在此，我们综述了近期关于银屑病相关微生物群的研究，试图确切识别银屑病患者的“核心”微生物群，了解微生物群在银屑病发病机制中的作用，并通过微生物干预探索银屑病的新治疗策略。
