Hwang Sun Wook, Oh Uhtaek
Korea University Graduate School of Medicine, College of Pharmacy, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, Korea.
Curr Opin Anaesthesiol. 2007 Oct;20(5):427-34. doi: 10.1097/ACO.0b013e3282eff91c.
A large number of channels that are in some way linked to sensory transduction including nociception have been discovered in recent years. This review summarizes newly discovered channels that are implicated in nociception. Furthermore, details are discussed with emphasis on their possible application to clinical use as analgesics.
Studies with null mutant animals deficient in these channel genes reveal that the channels are indeed implicated in physiological as well as pathological nociception.
Many transient receptor potential channels are thermosensors that detect cold, warm and hot temperatures. These channels are activated not only by natural chemicals such as capsaicin, menthol, and camphor, but by various inflammatory signaling pathways. The acid-sensing ion channel and P2X channel that detect extracellular acidosis and ATP are also implicated in some types of pain. Voltage-gated sodium or calcium channels draw attention because of their involvement in neuropathic pain.
近年来发现了大量以某种方式与包括伤害感受在内的感觉转导相关的通道。本综述总结了新发现的与伤害感受有关的通道。此外，还重点讨论了它们在临床用作镇痛药方面的可能应用细节。
对缺乏这些通道基因的基因敲除动物的研究表明，这些通道确实与生理性以及病理性伤害感受有关。
许多瞬时受体电位通道是检测冷、温和热温度的热传感器。这些通道不仅被辣椒素、薄荷醇和樟脑等天然化学物质激活，还被各种炎症信号通路激活。检测细胞外酸中毒和三磷酸腺苷（ATP）的酸敏感离子通道和P2X通道也与某些类型的疼痛有关。电压门控钠通道或钙通道因其与神经性疼痛有关而受到关注。
