Cakir D, Tosun A, Polat M, Celebisoy N, Gokben S, Aydogdu S, Yagci R V, Tekgul H
Department of Pediatrics, Ege University Medical School, Izmir, Turkey.
J Pediatr Gastroenterol Nutr. 2007 Sep;45(3):366-9. doi: 10.1097/MPG.0b013e31806907e8.
Because clinically evident manifestations are frequent in adults with celiac disease (CD), we aimed to investigate whether early neurological abnormalities may be detected in children with CD.
Electroencephalography, electromyography, and somatosensory evoked potentials were performed in children with CD receiving a gluten-free diet.
The neurophysiological tests revealed subclinical neurological abnormalities associated with CD in 3 (11%) of 27 children: 2 had peripheral polyneuropathy documented with electromyography, and 1 had prolonged latencies in somatosensory evoked potential. Magnetic resonance imaging showed abnormalities in 2 (7.4%) of children: pontine demyelinization in 1 and cortical atrophy in the other.
Because the rate of neurological problems is increased in children with CD, neurological abnormalities should be carefully investigated early after the diagnosis of CD is made.
由于乳糜泻（CD）在成人中常有明显的临床表现，我们旨在研究CD患儿是否能检测出早期神经异常。
对接受无麸质饮食的CD患儿进行脑电图、肌电图和体感诱发电位检查。
神经生理学检查发现，27例患儿中有3例（11%）存在与CD相关的亚临床神经异常：2例经肌电图证实有周围性多发性神经病，1例体感诱发电位潜伏期延长。磁共振成像显示2例（7.4%）患儿有异常：1例为脑桥脱髓鞘，另1例为皮质萎缩。
由于CD患儿神经问题发生率增加，因此在确诊CD后应尽早仔细检查神经异常情况。
