Kaji T, Inose K, Tsuchida A, Andoh K, Ohkubo Y, Ono K, Murakami H, Yano S, Omine M, Naruse T
Third Department of Internal Medicine, Gunma University School of Medicine, Japan.
J Med. 1991;22(4-5):225-41.
Two patients with systemic lupus erythematosus (SLE) and T-zone lymphoma are described. On admission, both showed arthralgia, generalized lymphadenopathy, hypergammaglobulinemia and positive antinuclear antibody. Lymph node biopsies revealed diffuse infiltration of atypical T-lymphocytes in the expanded interfollicular area (T-zone), a finding characteristic for the T-zone lymphoma. Renal biopsy showed lupus nephritis and neoplastic lymphoid cell infiltration in the glomeruli of one patient, but only diffuse infiltration of neoplastic lymphoid cells and mature plasma cells were observed in the interstitium of the other patient. Both patients responded remarkably well to prednisolone (1 mg/kg/day).
本文描述了两名患有系统性红斑狼疮（SLE）和T区淋巴瘤的患者。入院时，两人均表现出关节痛、全身淋巴结肿大、高球蛋白血症和抗核抗体阳性。淋巴结活检显示，在扩大的滤泡间区（T区）有非典型T淋巴细胞的弥漫性浸润，这是T区淋巴瘤的特征性表现。肾活检显示，一名患者的肾小球有狼疮性肾炎和肿瘤性淋巴细胞浸润，但另一名患者的间质中仅观察到肿瘤性淋巴细胞和成熟浆细胞的弥漫性浸润。两名患者对泼尼松龙（1mg/kg/天）均有显著反应。
