de Souza Luiz José, Nogueira Rita Maria Ribeiro, Soares Leandro Cordeiro, Soares Carlos Eduardo Cordeiro, Ribas Bruno Fernandes, Alves Felipe Pinto, Vieira Fabíola Rodrigues, Pessanha Felipe Eulálio Baldi
Dengue Reference Center, Oswaldo Cruz Institute, FIOCRUZ, Brazil.
Braz J Infect Dis. 2007 Aug;11(4):407-10. doi: 10.1590/s1413-86702007000400007.
The objective of this study was to evaluate the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from patients serologically diagnosed by according to two MAC-ELISA protocols. Degrees of liver damage were classified according to aminotransferase levels: grade A--normal enzyme levels; grade B--increased levels of at least one of the enzymes; grade C--increased, with at least one of the enzymes being at levels higher than three times the upper reference values; grade D--acute hepatitis, with aminotransferase levels at least ten times their normal values. Of the 169 serologically confirmed cases of dengue at the dengue referral center in Campos dos Goytacazes in the state of Rio de Janeiro, Brazil, 65.1% had abnormal aminotransferase levels: 81 cases being classified as grade B, 25 as grade C and 3 as grade D. A further 34.9% of cases had normal enzyme levels and were classified as grade A. Liver damage is a common complication of dengue infection and aminotransferase levels are a valuable marker for monitoring these cases.
本研究的目的是通过检测根据两种MAC-ELISA方案进行血清学诊断的患者血样中的转氨酶，评估登革热病毒感染对肝功能的影响。根据转氨酶水平对肝损伤程度进行分类：A级——酶水平正常；B级——至少一种酶水平升高；C级——升高，且至少有一种酶水平高于参考值上限的三倍；D级——急性肝炎，转氨酶水平至少为正常值的十倍。在巴西里约热内卢州坎波斯·多斯·戈伊塔卡泽斯登革热转诊中心血清学确诊的169例登革热病例中，65.1%的患者转氨酶水平异常：81例被分类为B级，25例为C级，3例为D级。另有34.9%的病例酶水平正常，被分类为A级。肝损伤是登革热感染的常见并发症，转氨酶水平是监测这些病例的重要指标。
