进行性系统性硬化症CREST变异型患者的干燥综合征。
Sjögren's syndrome in patients with the CREST variant of progressive systemic scleroderma.
作者信息
Drosos A A, Pennec Y L, Elisaf M, Lamour A, Acritidis N C, Jouquan J R, Moutsopoulos H M, Youinou P
机构信息
Department of Internal Medicine, School of Medicine, Universita of Ioannina, Greece.
出版信息
J Rheumatol. 1991 Nov;18(11):1685-8.
Twenty-three patients with the CREST (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia) variant of progressive systemic sclerosis, were clinically, histopathologically and serologically examined for the presence of Sjögren's syndrome (SS). Fourteen were found to be positive. No significant difference could be demonstrated between them and the remaining 9. Characteristics of patients with CREST were compared with those of 29 randomly chosen patients with primary SS. Parotid gland enlargement was more frequently present (p less than 0.01) in the latter than in the former. Virtually no patients with CREST with SS had antibodies to Ro(SSA)/La(SSB).
对23例患有进行性系统性硬化症的CREST（钙质沉着、雷诺现象、食管运动障碍、指端硬化、毛细血管扩张）变异型患者进行了临床、组织病理学和血清学检查，以确定是否存在干燥综合征（SS）。其中14例呈阳性。他们与其余9例之间未显示出显著差异。将CREST患者的特征与29例随机选择的原发性SS患者的特征进行了比较。后者腮腺肿大的发生率高于前者（p<0.01）。实际上，患有CREST合并SS的患者几乎没有抗Ro(SSA)/La(SSB)抗体。
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