Clement K, Langin D
Inserm, U872 Nutriomique, Paris, France.
J Intern Med. 2007 Oct;262(4):422-30. doi: 10.1111/j.1365-2796.2007.01851.x.
The identification of a moderate increase in circulating inflammatory factors in obese subjects, the description of changes in inflammatory gene expression in adipose tissue (AT) and the discovery that macrophage cells infiltrate AT are observations contributing to the concept that human obesity is a chronic inflammatory illness. This concept has led to some revision of the physiopathology of obesity and of its related metabolic and cardiovascular co-morbidities. Low-grade inflammation in the AT and the subsequent production of specific biomarkers could actually link expanded fat mass to obesity complications. This review aims at providing an overview of the current knowledge brought up by human gene expression studies, notably those performed on a large scale in AT depots. The regulation of specific biomarkers related to inflammation and putative new candidates (i.e. cathepsins and serum amyloid A) is discussed in the context of weight loss programmes based on calorie restriction and physical exercise. The foreseen clinical and technological challenges are also summarized.
在肥胖受试者中发现循环炎症因子适度增加、描述脂肪组织（AT）中炎症基因表达的变化以及发现巨噬细胞浸润AT，这些观察结果促使人们形成了人类肥胖是一种慢性炎症性疾病的概念。这一概念导致了对肥胖及其相关代谢和心血管合并症的生理病理学的一些修正。AT中的低度炎症以及随后特定生物标志物的产生实际上可能将脂肪量增加与肥胖并发症联系起来。本综述旨在概述人类基因表达研究，特别是在AT库中大规模开展的研究，所带来的当前知识。在基于热量限制和体育锻炼的减肥计划背景下，讨论了与炎症相关的特定生物标志物以及假定的新候选物（即组织蛋白酶和血清淀粉样蛋白A）的调控。还总结了可预见的临床和技术挑战。
