Students' Scientific Center, Tehran University of Medical Sciences, PO Box 1417755331, Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran.
BMC Res Notes. 2020 Apr 14;13(1):212. doi: 10.1186/s13104-020-04976-9.
Obesity plays an important role in the development of chronic diseases like cardiovascular diseases and diabetes. The possible underlying mechanism for this connection is that adipose tissue secretes an array of chemical messenger adipokines proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, and interleukin-1-beta). This study aimed to investigate the linkage between adipocytokines and insulin with the cardiovascular disease risk, with particular reference to the adipokines galectin-3, plasminogen activator inhibitor-1, and interleukin-1-beta, C-reactive protein, and monocyte chemoattractant protein.
Two patterns were identified. The first pattern was galectin-3, plasminogen activator inhibitor-1 and interleukin-1-beta and the second one was C-reactive protein, insulin and monocyte chemoattractant protein-1. The second pattern was strongly associated with the higher scores for resting metabolic rate, diastolic blood pressure, homeostasis model insulin resistance index, lipid profile (except low density lipoprotein, total cholesterol), and body composition parameters (except fat free mass index and waist hip ratio), while negatively associated with age and high density lipoprotein level (all p < 0.05). The first pattern was, however, significantly associated with body fat mass, obesity degree percentage, waist circumference, fat mass index, and waist hip ratio (p < 0.05 for all). This is a retrospective study. Ethics approval (IR.TUMS.VCR.REC.1395.1597).
肥胖在心血管疾病和糖尿病等慢性病的发展中起着重要作用。这种联系的潜在机制可能是脂肪组织分泌一系列化学信使脂肪因子——促炎细胞因子（肿瘤坏死因子-α、白细胞介素-6 和白细胞介素-1-β）。本研究旨在探讨脂肪细胞因子与胰岛素与心血管疾病风险之间的联系，特别关注脂肪因子半乳糖凝集素-3、纤溶酶原激活物抑制剂-1 和白细胞介素-1-β、C 反应蛋白和单核细胞趋化蛋白。
确定了两种模式。第一种模式是半乳糖凝集素-3、纤溶酶原激活物抑制剂-1 和白细胞介素-1-β，第二种模式是 C 反应蛋白、胰岛素和单核细胞趋化蛋白-1。第二种模式与静息代谢率、舒张压、稳态模型胰岛素抵抗指数、血脂谱（除低密度脂蛋白、总胆固醇）和身体成分参数（除无脂肪质量指数和腰臀比）的较高评分密切相关，而与年龄和高密度脂蛋白水平呈负相关（均 p<0.05）。然而，第一种模式与体脂肪量、肥胖程度百分比、腰围、脂肪质量指数和腰臀比显著相关（均 p<0.05）。这是一项回顾性研究。伦理批准（IR.TUMS.VCR.REC.1395.1597）。
