Childs C C, Hirsch-Ginsberg C, Culbert S J, Ahearn M, Reuben J, Trujillo J M, Cork A, Walters R R, Freireich E J, Stass S A
Division of Laboratory Medicine, University of Texas System Cancer Center, Houston 77030.
Hematol Pathol. 1988;2(3):145-57.
Acute leukemia associated with the t(4;11)(q21;q23) abnormality demonstrates marked lineage heterogeneity, including cases with features of acute mixed lineage leukemia. We report 7 patients with acute leukemia with the t(4;11) abnormality in which we have defined the range of lineage commitment associated with this disease utilizing a variety of cell characterization techniques. Each case could be classified either as acute lymphoblastic leukemia (ALL) (5 cases) or acute myelogenous leukemia (AML) (2 cases) based on standard light microscopic criteria supplemented by ultrastructural determination of myeloperoxidase. Evidence for acute mixed lineage leukemia was found in one of the AML patients in which coexpression of CD14 and CD19 surface antigens was demonstrated. Overall, the findings further confirm the lineage heterogeneity previously reported in association with t(4;11) acute leukemia. The implications of the findings as to the pathogenesis of t(4;11) acute leukemia are discussed.
与t(4;11)(q21;q23)异常相关的急性白血病表现出明显的谱系异质性，包括具有急性混合谱系白血病特征的病例。我们报告了7例患有t(4;11)异常的急性白血病患者，我们利用多种细胞表征技术确定了与该疾病相关的谱系定向范围。根据标准光学显微镜标准并辅以髓过氧化物酶的超微结构测定，每个病例可分类为急性淋巴细胞白血病（ALL）（5例）或急性髓细胞白血病（AML）（2例）。在1例AML患者中发现了急性混合谱系白血病的证据，该患者表现出CD14和CD19表面抗原的共表达。总体而言，这些发现进一步证实了先前报道的与t(4;11)急性白血病相关的谱系异质性。本文讨论了这些发现对t(4;11)急性白血病发病机制的影响。
