Cirioni Oscar, Ghiselli Roberto, Minardi Daniele, Orlando Fiorenza, Mocchegiani Federico, Silvestri Carmela, Muzzonigro Giovanni, Saba Vittorio, Scalise Giorgio, Balaban Naomi, Giacometti Andrea
Institute of Infectious Diseases and Public Health, Polytechnic University of the Marche Region, A.O. Ospedali Riuniti, Ancona, Italy.
Antimicrob Agents Chemother. 2007 Dec;51(12):4518-20. doi: 10.1128/AAC.00808-07. Epub 2007 Sep 17.
Ureteral stents coated with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rat bladders and shown to suppress Staphylococcus aureus formation on the stent and in urine and was especially effective when combined with teicoplanin. Coating ureteral stents with RIP thus increases the efficacy of teicoplanin in preventing ureteral stent-associated staphylococcal infections.
将涂有群体感应抑制剂RNAIII抑制肽（RIP）的输尿管支架植入大鼠膀胱，结果显示该支架可抑制支架表面及尿液中金黄色葡萄球菌的形成，与替考拉宁联合使用时效果尤为显著。因此，用RIP包被输尿管支架可提高替考拉宁预防输尿管支架相关葡萄球菌感染的疗效。
