Simonetti Oriana, Rizzetto Giulio, Radi Giulia, Molinelli Elisa, Cirioni Oscar, Giacometti Andrea, Offidani Annamaria
Department of Clinical and Molecular Sciences Clinic of Dermatology, Polytechnic University of Marche, 60020 Ancona, Italy.
Department of Biomedical Sciences and Public Health Clinic of Infectious Diseases, Polytechnic University of Marche, 60020 Ancona, Italy.
Antibiotics (Basel). 2021 Nov 10;10(11):1377. doi: 10.3390/antibiotics10111377.
Among the most common complications of both chronic wound and surgical sites are staphylococcal skin infections, which slow down the wound healing process due to various virulence factors, including the ability to produce biofilms. Furthermore, staphylococcal skin infections are often caused by methicillin-resistant (MRSA) and become a therapeutic challenge. The aim of this narrative review is to collect the latest evidence on old and new anti-staphylococcal therapies, assessing their anti-biofilm properties and their effect on skin wound healing. We considered antibiotics, quorum sensing inhibitors, antimicrobial peptides, topical dressings, and antimicrobial photo-dynamic therapy. According to our review of the literature, targeting of biofilm is an important therapeutic choice in acute and chronic infected skin wounds both to overcome antibiotic resistance and to achieve better wound healing.
葡萄球菌皮肤感染是慢性伤口和手术部位最常见的并发症之一，由于包括产生生物膜能力在内的各种毒力因子，它会减缓伤口愈合过程。此外，葡萄球菌皮肤感染通常由耐甲氧西林金黄色葡萄球菌（MRSA）引起，成为一个治疗挑战。本叙述性综述的目的是收集有关新旧抗葡萄球菌疗法的最新证据，评估它们的抗生物膜特性及其对皮肤伤口愈合的影响。我们考虑了抗生素、群体感应抑制剂、抗菌肽、局部敷料和抗菌光动力疗法。根据我们对文献的综述，针对生物膜是急性和慢性感染性皮肤伤口的重要治疗选择，既能克服抗生素耐药性，又能实现更好的伤口愈合。
