Ramesh B, Saravanan R, Pugalendi K V
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamilnadu, India.
Yale J Biol Med. 2006 Mar;79(1):9-17.
The effect of groundnut oil on blood glucose, lipid profile, lipid peroxidation, and antioxidant status in streptozotocin-diabetic rats was investigated and compared with diabetic and drug-treated rats. Diabetes was induced in adult female Wistar rats by intraperitoneal administration of streptozotocin (40 mg/kg b-wt). Normal and diabetic rats were fed an oil-free diet containing 2 percent oil supplemented with groundnut oil (6g per 94 g diet), to give 8 percent oil content, for 42 days. Diabetic rats had elevated levels of glucose (322.61 +/- 9.49), glycosylated hemoglobin (HbA(1c)), vitamin E, thiobarbituric acid reactive substances (TBARS), and lipid hydroperoxides (HP) and decreased levels of hemoglobin (Hb), vitamin C, and reduced glutathione (GSH). An increase in the activities of glucose-6-phosphatase and fructose-1,6-bisphosphatase and a decrease in hexokinase activity also were observed in the liver and kidney. When diabetic rats were fed groundnut oil, a significant reduction in glucose (244.04 +/- 11.66), HbA(1c), TBARS, HP levels, and glucose-6-phosphatase and fructose-1,6-bisphosphatase activities and an elevation in Hb, vitamin E, GSH levels, and hexokinase activity were observed. Diabetic rats had elevated total cholesterol (TC), VLDL-cholesterol, LDL-cholesterol, and triglycerides (TG) and decreased HDL-cholesterol. Diabetic rats fed groundnut oil showed a small but significant reduction in TC, VLDL-C, LDL-C, and TG and an elevation in HDL-C. Groundnut oil consumption slightly but significantly decreases the blood glucose, HbA(1c), lipid peroxidation, and lipid profile and increases antioxidant levels in diabetic rats.
研究了花生油对链脲佐菌素诱导的糖尿病大鼠血糖、血脂谱、脂质过氧化和抗氧化状态的影响，并与糖尿病大鼠和药物治疗的大鼠进行了比较。通过腹腔注射链脲佐菌素（40mg/kg体重）诱导成年雌性Wistar大鼠患糖尿病。正常大鼠和糖尿病大鼠喂食不含油的饮食，该饮食含有2%的油并补充花生油（每94g饮食中含6g），使油含量达到8%，持续42天。糖尿病大鼠的血糖（322.61±9.49）、糖化血红蛋白（HbA1c）、维生素E、硫代巴比妥酸反应物质（TBARS）和脂质氢过氧化物（HP）水平升高，而血红蛋白（Hb）、维生素C和还原型谷胱甘肽（GSH）水平降低。在肝脏和肾脏中还观察到葡萄糖-6-磷酸酶和果糖-1,6-二磷酸酶活性增加，己糖激酶活性降低。当糖尿病大鼠喂食花生油时，血糖（244.04±11.66）、HbA1c、TBARS、HP水平以及葡萄糖-6-磷酸酶和果糖-1,6-二磷酸酶活性显著降低，而Hb、维生素E和GSH水平以及己糖激酶活性升高。糖尿病大鼠的总胆固醇（TC）、极低密度脂蛋白胆固醇（VLDL-C）、低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG）升高，高密度脂蛋白胆固醇（HDL-C）降低。喂食花生油的糖尿病大鼠的TC、VLDL-C、LDL-C和TG略有但显著降低，HDL-C升高。食用花生油可轻微但显著降低糖尿病大鼠的血糖、HbA1c、脂质过氧化和血脂谱，并提高抗氧化水平。
