van der Oord Saskia, Prins P J M, Oosterlaan J, Emmelkamp P M G
Dept. of Clinical Psychology, University of Amsterdam, Roeterstraat 15, Amsterdam 1018 WB, The Netherlands.
Eur Child Adolesc Psychiatry. 2008 Mar;17(2):73-81. doi: 10.1007/s00787-007-0638-8. Epub 2007 Sep 14.
The present study investigated the predictive power of anxiety, IQ, severity of ADHD and parental depression on the outcome of treatment in children with ADHD.
Fifty children with ADHD (ages 8-12) were randomized to a 10-week treatment of methylphenidate or to a treatment of methylphenidate combined with multimodal behavior therapy. Prior to treatment predictors were assessed. Outcome was assessed separately for parents and teachers on a composite measure of inattentive, hyperactive, oppositional- and conduct disorder symptoms.
There was neither a significant difference between the two treatments at baseline nor did treatment condition predict outcome. Therefore the data were collapsed across the two treatments. A combination of anxiety and IQ predicted teacher-rated outcome, explaining 18% of the variance. Higher anxiety and higher IQ's indicated better treatment outcome. There were no significant predictors of the parent-rated outcome.
This study showed a small but significant predictive effect of IQ and anxiety on treatment outcome in children with ADHD.
This study supports the idea that for the treatment of ADHD children with comorbid anxiety and higher IQ respond better to the two most used treatments for ADHD.
本研究探讨焦虑、智商、注意力缺陷多动障碍（ADHD）的严重程度及父母抑郁对ADHD儿童治疗结果的预测作用。
50名ADHD儿童（8 - 12岁）被随机分为两组，一组接受为期10周的哌甲酯治疗，另一组接受哌甲酯联合多模式行为治疗。在治疗前对预测因素进行评估。分别根据父母和教师对注意力不集中、多动、对立违抗和品行障碍症状的综合测量来评估治疗结果。
两种治疗在基线时无显著差异，治疗条件也不能预测结果。因此，将两种治疗的数据合并。焦虑和智商的组合可预测教师评定的结果，解释了18%的方差。较高的焦虑水平和较高的智商表明治疗结果较好。父母评定的结果没有显著的预测因素。
本研究表明智商和焦虑对ADHD儿童的治疗结果有微小但显著的预测作用。
本研究支持这样的观点，即对于合并焦虑且智商较高的ADHD儿童，这两种最常用的ADHD治疗方法疗效更佳。
