脂肪细胞脂质滴的新视角：在三酰甘油储存感知中发挥作用？
A new look at adipocyte lipid droplets: towards a role in the sensing of triacylglycerol stores?
作者信息
Dugail I, Hajduch E
机构信息
INSERM, U872, Paris, 75006, France.
出版信息
Cell Mol Life Sci. 2007 Oct;64(19-20):2452-8. doi: 10.1007/s00018-007-7277-6.
Abstract
Lipid droplets have been considered for a long time as inert intracytoplasmic deposits formed within cells under various conditions. Recently, new tools and new approaches have been used to visualize and study these intracellular structures. This revealed new aspects of lipid droplets biology and pointed out their organized structure and dynamic composition. In adipocytes, the specialized cell type for the storage of energy as fat, lipid droplets are particularly well-developed organelles and exhibit unique properties. Also discussed in this paper is the view that lipid droplets, through specific candidate constituents, can play a role in sensing the level of their lipid stores by adipocytes.
摘要
长期以来，脂滴一直被认为是细胞在各种条件下形成的惰性胞质内沉积物。最近，新的工具和方法被用于观察和研究这些细胞内结构。这揭示了脂滴生物学的新方面，并指出了它们的组织结构和动态组成。在脂肪细胞中，作为储存脂肪能量的特殊细胞类型，脂滴是特别发达的细胞器，并具有独特的特性。本文还讨论了一种观点，即脂滴通过特定的候选成分，可以在脂肪细胞感知其脂质储存水平方面发挥作用。
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