Atkinson Meredith A, Neu Alicia M, Fivush Barbara A, Frankenfield Diane L
Pediatric Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pediatr Nephrol. 2007 Nov;22(11):1939-46. doi: 10.1007/s00467-007-0593-0. Epub 2007 Sep 18.
Ethnicity information was collected for all pediatric peritoneal dialysis patients from the End-Stage Renal Disease (ESRD) Clinical Performance Measures (CPM) Project for the period October 2004 through March 2005. Associations between intermediate outcomes and Hispanic ethnicity were determined. Thirty percent (207/696) of patients in the final cohort were Hispanic, 24% (165/696) non-Hispanic black, and 46% (324/696) non-Hispanic white. Hispanics were more likely to be female, older, and have a lower mean height standard deviation score (SDS). There were no significant differences among ethnic/racial groups regarding clearance parameters. More Hispanics had a mean hemoglobin > or = 11 g/dl compared with non-Hispanic blacks and non-Hispanic whites (77% vs. 55% and 70%, P < 0.0001). More Hispanics compared with non-Hispanic blacks and non-Hispanic whites had a mean serum albumin > or = 4.0/3.7 g/dl [bromcresol green/bromcresol purple laboratory method (BCG/BCP)] (50% vs. 24% and 27%, respectively, P < 0.0001). In multivariate analyses, Hispanics remained significantly more likely to achieve a mean serum albumin > or = 4.0/3.7 g/dl (BCG/BCP) compared with non-Hispanic whites (referent) and were as likely to achieve clearance and hemoglobin targets. Pediatric Hispanic peritoneal dialysis patients experience equivalent or better intermediate outcomes of dialytic care compared with non-Hispanics. Further study is needed to understand associations of Hispanic ethnicity with outcomes such as hospitalization, transplantation, and mortality.
从2004年10月至2005年3月的终末期肾病(ESRD)临床绩效指标(CPM)项目中收集了所有儿科腹膜透析患者的种族信息。确定了中间结局与西班牙裔种族之间的关联。最终队列中的患者有30%(207/696)为西班牙裔,24%(165/696)为非西班牙裔黑人,46%(324/696)为非西班牙裔白人。西班牙裔患者更可能为女性、年龄较大,且平均身高标准差评分(SDS)较低。各种族/民族群体在清除参数方面无显著差异。与非西班牙裔黑人和非西班牙裔白人相比,更多西班牙裔患者的平均血红蛋白≥11 g/dl(77% 对55% 和70%,P < 0.0001)。与非西班牙裔黑人和非西班牙裔白人相比,更多西班牙裔患者的平均血清白蛋白≥4.0/3.7 g/dl [溴甲酚绿/溴甲酚紫实验室方法(BCG/BCP)](分别为50% 对24% 和27%,P < 0.0001)。在多变量分析中,与非西班牙裔白人(参照组)相比,西班牙裔患者仍显著更有可能达到平均血清白蛋白≥4.0/3.7 g/dl(BCG/BCP),且达到清除和血红蛋白目标的可能性相同。与非西班牙裔患者相比,儿科西班牙裔腹膜透析患者在透析治疗的中间结局方面相当或更好。需要进一步研究以了解西班牙裔种族与住院、移植和死亡率等结局之间的关联。