Heino Jyrki
Department of Biochemistry and Food Chemistry, University of Turku, Arcanum, Vatselankatu 2, FI-20014 Turku, Finland.
Bioessays. 2007 Oct;29(10):1001-10. doi: 10.1002/bies.20636.
The collagen family of extracellular matrix proteins has played a fundamental role in the evolution of multicellular animals. At the present, 28 triple helical proteins have been named as collagens and they can be divided into several subgroups based on their structural and functional properties. In tissues, the cells are anchored to collagenous structures. Often the interaction is indirect and mediated by matrix glycoproteins, but cells also express receptors, which have the ability to directly bind to the triple helical domains in collagens. Some receptors bind to sites that are abundant in all collagens. However, increasing evidence indicates that the coevolution of collagens and cell adhesion mechanisms has given rise to receptors that bind to specific motifs in collagens. These receptors may also recognize the different members of the large collagen family in a selective manner. This review summarizes the present knowledge about the properties of collagen subtypes as cell adhesion proteins.
细胞外基质蛋白的胶原蛋白家族在多细胞动物的进化过程中发挥了重要作用。目前，已有28种三螺旋蛋白被命名为胶原蛋白，根据其结构和功能特性可分为几个亚组。在组织中，细胞锚定在胶原结构上。这种相互作用通常是间接的，由基质糖蛋白介导，但细胞也表达能够直接结合胶原蛋白三螺旋结构域的受体。一些受体结合所有胶原蛋白中都丰富的位点。然而，越来越多的证据表明，胶原蛋白与细胞黏附机制的共同进化产生了能够结合胶原蛋白中特定基序的受体。这些受体也可能以选择性方式识别大型胶原蛋白家族的不同成员。本综述总结了目前关于胶原蛋白亚型作为细胞黏附蛋白特性的知识。
