Fu Xueyan, Booth Sarah L, Smith Donald E
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
J Am Assoc Lab Anim Sci. 2007 Sep;46(5):8-12.
Adequate nutrient intake is critical in the maintenance of normal physiologic activity of rodents in biomedical studies. Vitamin K is an essential nutrient in rodent diets and functions as a cofactor for the gamma-carboxylation of various proteins involved in blood coagulation and bone metabolism. Several forms of vitamin K are used in rodent diets, with a shift during the last decade towards the use of phylloquinone, the predominant form in human diets, and a concomitant increase in concentrations. This review summarizes current recommendations for vitamin K in rodent diets relative to our evolving knowledge about this fat-soluble vitamin.
在生物医学研究中，充足的营养摄入对于维持啮齿动物的正常生理活动至关重要。维生素K是啮齿动物饮食中的一种必需营养素，作为参与血液凝固和骨代谢的各种蛋白质γ-羧化作用的辅助因子发挥作用。啮齿动物饮食中使用了几种形式的维生素K，在过去十年中，使用趋势转向了叶绿醌（人类饮食中的主要形式），且其浓度随之增加。本综述总结了啮齿动物饮食中维生素K的当前建议，这些建议与我们对这种脂溶性维生素不断发展的认识相关。
