Jean Mayer USDA Human Nutrition Research Center On Aging at Tufts University, 711 Washington St, Boston, MA, USA.
Agricultural Research Service, US Department of Agriculture, Western Human Nutrition Research Center, Davis, CA, USA.
Geroscience. 2023 Jun;45(3):2079-2084. doi: 10.1007/s11357-023-00775-9. Epub 2023 Apr 20.
Chow diet is used in the majority of rodent studies and, although assumed to be standardized for dietary source and nutritional contents, it varies widely across commercial formulations. Similarly, current approaches to study aging in rodents involve a single-diet formulation across the lifespan and overlook age-specific nutritional requirements, which may have long-term effects on aging processes. Together, these nutrition-based disparities represent major gaps in geroscience research, affecting the interpretation and reproducibility of the studies. This perspective aims to raise awareness on the importance of rodent diet formulation and proposes that geroscientists include detailed descriptions of all experimental diets and feeding protocols. Detailed reporting of diets will enhance rigor and reproducibility of aging rodent studies and lead to more translational outcomes in geroscience research.
中式饮食在大多数啮齿类动物研究中被采用，尽管被认为在饮食来源和营养成分方面是标准化的，但在商业配方中差异很大。同样，目前研究啮齿动物衰老的方法涉及整个生命周期中的单一饮食配方，而忽略了特定年龄的营养需求，这可能对衰老过程产生长期影响。这些基于营养的差异共同构成了衰老科学研究中的主要空白，影响了研究的解释和可重复性。本观点旨在提高对啮齿类动物饮食配方重要性的认识，并提出衰老科学家应包括所有实验饮食和喂养方案的详细描述。详细报告饮食将提高衰老啮齿动物研究的严谨性和可重复性，并在衰老科学研究中带来更多的转化结果。
