Guo Xiao-qiang
Department of Biochemistry, Bethune Military Medical College, Shijiazhuang 050081, China.
Zhonghua Yi Shi Za Zhi. 2007 Apr;37(2):94-7.
Signal transduction is one of the most important fields of life science. The discovery of cAMP and description of the second messenger hypothesis by Sutherland is the landmark of signal transduction. In this paper, the background and course of cAMP discovery were demonstrated and at the same time the content and significance of the second messenger hypothesis were illustrated, so scientific contribution of the second messenger hypothesis can be approximately understood.
信号转导是生命科学最重要的领域之一。环磷酸腺苷（cAMP）的发现以及萨瑟兰对第二信使假说的描述是信号转导的里程碑。本文阐述了cAMP发现的背景和过程，同时说明了第二信使假说的内容和意义，从而可以大致了解第二信使假说的科学贡献。
