de Carlos Felix, Cobo Juan, Perillan Carmen, Garcia Miguel A, Arguelles Juan, Vijande Manuel, Costales Marina
Departamento de Cirugia y Especialidades Medico-Quirurgicas, Servicio de Ortodoncia, Universidad de Oviedo, C/Catedrático José Serrano, 33006 Oviedo, Spain.
Eur J Orthod. 2007 Dec;29(6):596-9. doi: 10.1093/ejo/cjm072. Epub 2007 Sep 18.
Anti-inflammatory substances used for treatment of pain and discomfort related to orthodontic treatment (OT) could slow down tooth movement. Selective cyclooxygenase-2 inhibitors are an alternative to conventional non-steroidal anti-inflammatory drugs. The aim of this study was to compare different coxibs on dental movement in the rat. Twenty-eight Wistar male rats (3 months old) divided into four experimental groups were studied: (1) Five rats underwent a 50 g coil spring implantation and received three injections of 0.5 mg/kg body weight (bw) of Rofecoxib in the maxillary gingiva, close to the first molar, on the day of implantation and after 3 and 5 days. Similar procedures were carried out (2) on six animals receiving 8 mg/kg bw of Celecoxib and (3) on five animals receiving 25 mg/kg bw of Parecoxib. (4) For the controls, 12 rats received the same OT but only equivolumetric 0.9 per cent saline solution injections. Tooth movement was measured on lateral cranial teleradiographs after 10 days of treatment. Non-parametric standard techniques (Wilcoxon, H, and Mann-Whitney, U) were used for statistical analysis. Mesial tooth displacement in the control animals was 0.33 +/- 0.07 mm. While no movement was found in rats treated with Rofecoxib, the Celecoxib- and Parecoxib-treated rats showed tooth movement of 0.42 +/- 0.09 mm and 0.22 +/- 0.04 mm, respectively. The differences were statistically significant (H = 13.07; P < 0.004). Celecoxib and Parecoxib, but not Rofecoxib, seem appropriate for discomfort and pain relief while avoiding interference during tooth movement.
用于治疗与正畸治疗（OT）相关的疼痛和不适的抗炎物质可能会减缓牙齿移动。选择性环氧化酶-2抑制剂是传统非甾体抗炎药的一种替代药物。本研究的目的是比较不同的环氧化酶-2抑制剂对大鼠牙齿移动的影响。将28只3个月大的雄性Wistar大鼠分为四个实验组进行研究：（1）5只大鼠接受50 g螺旋弹簧植入，并在植入当天以及3天和5天后于上颌第一磨牙附近的牙龈处接受三次0.5 mg/kg体重的罗非昔布注射。对（2）6只接受8 mg/kg体重塞来昔布的动物以及（3）5只接受25 mg/kg体重帕瑞昔布的动物进行了类似的操作。（4）对于对照组，12只大鼠接受相同的正畸治疗，但仅注射等体积的0.9%生理盐水。治疗10天后，在头颅侧位X线片上测量牙齿移动情况。采用非参数标准技术（Wilcoxon检验、H检验和Mann-Whitney检验、U检验）进行统计分析。对照动物的牙齿近中位移为0.33±0.07 mm。在用罗非昔布治疗的大鼠中未发现牙齿移动，而用塞来昔布和帕瑞昔布治疗的大鼠牙齿移动分别为0.42±0.09 mm和0.22±0.04 mm。差异具有统计学意义（H = 13.07；P < 0.004）。塞来昔布和帕瑞昔布似乎适合缓解不适和疼痛，同时避免在牙齿移动过程中产生干扰，而罗非昔布则不适合。
