Ingelsson Erik, Sundström Johan, Melhus Håkan, Michaëlsson Karl, Berne Christian, Vasan Ramachandran S, Risérus Ulf, Blomhoff Rune, Lind Lars, Arnlöv Johan
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Atherosclerosis. 2009 Sep;206(1):239-44. doi: 10.1016/j.atherosclerosis.2009.02.029. Epub 2009 Mar 11.
Our aim was to examine relations of serum retinol-binding protein 4 (RBP4) to cardiovascular risk factors, and prevalent metabolic syndrome (MetS) and cardiovascular disease (CVD) in a large community-based sample of elderly.
We evaluated cross-sectional relations of serum RBP4 to cardiovascular risk factors including anthropometrical measures, blood pressure, lipid measures, fasting glucose and insulin, body fat distribution including truncal fat by dual-energy x-ray absorptiometry (DXA), homeostasis model assessment insulin resistance (HOMA-IR) and prevalent MetS in one thousand eight 70-year old participants (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), and in five hundred seven 82-year old men from Uppsala Longitudinal Study of Adult Men (ULSAM). In ULSAM, we also examined associations with prevalent CVD.
RBP4 concentrations were positively correlated with serum triglycerides (r=0.30; P<0.0001 in both samples), whereas correlations with body mass index (BMI), waist circumference, sagittal abdominal diameter, total and truncal fat mass, total cholesterol, fasting glucose and HOMA-IR were weak. In multivariable-adjusted models, RBP-4 was associated with MetS (odds ratio (OR), 1.16 and 1.33; 95% confidence interval (CI), 0.99-1.37 and 1.05-1.67 per 1-standard deviation (SD) increase in PIVUS and ULSAM, respectively), and prior cerebrovascular disease (OR, 1.37; 95% CI, 1.00-1.88 per 1-SD increase in ULSAM), but not with prior myocardial infarction.
In elderly, RBP4 concentrations were associated with MetS and its components in both sexes, and prior cerebrovascular disease in men. These findings are consistent with the hypothesis that circulating RBP4 could be a marker of metabolic complications and possibly also atherosclerosis and overt CVD.
我们的目的是在一个基于社区的大型老年样本中，研究血清视黄醇结合蛋白4（RBP4）与心血管危险因素、代谢综合征（MetS）和心血管疾病（CVD）的关系。
我们在乌普萨拉老年人血管前瞻性研究（PIVUS）的1870名70岁参与者（50%为女性）以及乌普萨拉成年男性纵向研究（ULSAM）的507名82岁男性中，评估了血清RBP4与心血管危险因素的横断面关系，这些危险因素包括人体测量指标、血压、血脂指标、空腹血糖和胰岛素、通过双能X线吸收法（DXA）测量的身体脂肪分布（包括躯干脂肪）、稳态模型评估胰岛素抵抗（HOMA-IR）以及MetS的患病率。在ULSAM中，我们还研究了其与CVD患病率的关联。
RBP4浓度与血清甘油三酯呈正相关（r = 0.30；两个样本中P均<0.000），而与体重指数（BMI）、腰围、腹径、总脂肪量和躯干脂肪量、总胆固醇、空腹血糖和HOMA-IR的相关性较弱。在多变量调整模型中，在PIVUS和ULSAM中，每增加1个标准差（SD），RBP-4分别与MetS相关（比值比（OR）分别为1.16和1.33；95%置信区间（CI）分别为0.99 - 1.37和1.05 - 1.67），以及与既往脑血管疾病相关（在ULSAM中，每增加1个SD，OR为1.37；95%CI为1.00 - 1.88），但与既往心肌梗死无关。
在老年人中，RBP4浓度与男女的MetS及其组成成分相关，并且与男性的既往脑血管疾病相关。这些发现与循环RBP分子可能是代谢并发症以及可能也是动脉粥样硬化和显性CVD的标志物这一假设一致。
