Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Endocrinol (Lausanne). 2022 May 11;13:880467. doi: 10.3389/fendo.2022.880467. eCollection 2022.
We aimed to investigate the association of circulating retinol-binding protein-4 (RBP4) levels with long-term cardiometabolic risk profiles and whether sex disparity mattered.
We included 784 non-diabetic participants aged 40 years and above from a well-defined community-based cohort at baseline in 2005 and they were invited to attend the on-site follow-up examination for two consecutive times with 3-year intervals in 2008 and 2011, respectively. Serum RBP4 was measured at baseline, and the anthropometry and biochemical measurements were performed at each visit. Generalized estimating equation models were used to assess the association of serum RBP4 levels with the dynamic changes in adiposity and glucolipid profile.
Based on all the baseline and the 3- and 6-year follow-up data, baseline serum RBP4 levels (each 1-unit of logRBP4) were significantly associated with waist circumference [β=3.12, 95% confidence interval (CI) (0.77, 5.47), P=0.01], fasting, and 2-h post-loading glucose [β=0.26 (0.05, 0.47), P=0.02, and 1.70 (1.29, 2.12), P< 0.0001], serum triglycerides [β=0.75, 95% CI (0.54, 0.96), P< 0.0001], total cholesterol [β=0.47, 95% CI [0.23 0.70], P<0.0001), and marginally with body mass index (β=0.97, 95% CI (0.02, 1.93), P=0.046], in total participants, after adjusting potential confounders. The association of RBP4 with 2-h post-loading glucose was stronger in women than that in men [β=1.99, 95% CI (1.49, 2.50) vs. 0.61 (-0.14, 1.36), P for interaction=0.001]. The analysis of change in Z-score of cardiometabolic profiles corresponding to each 1-unit increment in logRBP4 showed consistent results.
Higher RBP4 levels are associated with longitudinal increase in adiposity and deteriorated glucolipid profile defined by repeated measurements. The associations differ in sex regarding to the 2-h post-loading glucose.
我们旨在探究循环视黄醇结合蛋白 4（RBP4）水平与长期心脏代谢风险谱之间的关联，以及这种关联是否存在性别差异。
我们纳入了 2005 年来自一个明确界定的社区队列中的 784 名年龄在 40 岁及以上的非糖尿病患者，他们在基线时被邀请参加两次现场随访检查，两次检查的时间间隔分别为 3 年，分别为 2008 年和 2011 年。在基线时测量血清 RBP4，在每次就诊时进行人体测量和生化测量。使用广义估计方程模型评估血清 RBP4 水平与体重指数和糖脂谱动态变化之间的关系。
基于所有基线和 3 年及 6 年随访数据，基线血清 RBP4 水平（每单位 logRBP4）与腰围[β=3.12，95%置信区间（CI）（0.77，5.47），P=0.01]、空腹和负荷后 2 小时血糖[β=0.26（0.05，0.47），P=0.02，和 1.70（1.29，2.12），P<0.0001]、血清甘油三酯[β=0.75，95%CI（0.54，0.96），P<0.0001]、总胆固醇[β=0.47，95%CI（0.23 0.70），P<0.0001]显著相关，且与体重指数（β=0.97，95%CI（0.02，1.93），P=0.046）呈边际相关，在调整了潜在混杂因素后，在所有参与者中均如此。在女性中，RBP4 与负荷后 2 小时血糖之间的关联强于男性[β=1.99，95%CI（1.49，2.50）比 0.61（-0.14，1.36），P 交互=0.001]。分析每增加 1 个单位 logRBP4 对应的心脏代谢特征 Z 评分变化，得到了一致的结果。
较高的 RBP4 水平与通过重复测量定义的体重指数增加和糖脂谱恶化相关。关于负荷后 2 小时血糖，这种关联在性别上存在差异。
