Semerjian Lucy, Dennis John
Department of Civil and Environmental Engineering, American University of Beirut, Beirut, Lebanon.
J Water Health. 2007 Dec;5(4):511-22. doi: 10.2166/wh.2007.046.
The toxicological risks and lifetime cancer risks of trihalomethanes through oral ingestion, dermal absorption, and inhalation exposure from tap water in selected regions in Lebanon are estimated. Existing trihalomethane concentrations do not pose any non-carcinogenic and developmental risks in the exposed population via oral ingestion. Among the three pathways, residents have a higher risk of cancer through oral ingestion than through the other two pathways. The lifetime cancer risk through oral ingestion for dibromochloromethane makes the highest contribution to total risks, followed by bromodichloromethane, bromoform, and chloroform. The total multipathway cancer risk analysis suggests that no cancer risks exist during the summer and winter seasons; however, in the spring the total cancer risks exceeds the USEPA acceptable level of 10(-6) by a factor of 10.7.
对黎巴嫩特定地区自来水中三卤甲烷经口摄入、皮肤吸收和吸入暴露的毒理学风险及终生癌症风险进行了估算。现有三卤甲烷浓度通过经口摄入不会对暴露人群造成任何非致癌和发育风险。在这三种途径中,居民经口摄入患癌风险高于其他两种途径。二溴一氯甲烷经口摄入的终生癌症风险对总风险的贡献最大,其次是一溴二氯甲烷、溴仿和氯仿。多途径总癌症风险分析表明,夏季和冬季不存在癌症风险;然而,春季总癌症风险超过美国环境保护局可接受水平10(-6)的10.7倍。