Bennacer Amira Fatma, Haffaf Elmahdi, Kacimi Ghouti, Oudjit Brahim, Koceir Elhadj-Ahmed
Laboratoire de biologie et physiologie des organismes, Équipe de bioénergétique et métabolisme intermédiaire, Université des sciences et de la technologie Houari Boumediene, Faculté des sciences biologiques, Alger, Algérie.
Service de médecine nucléaire, Hôpital Central de l'Armée, Hôpital Mohamed Seghir Nekache, Alger, Algérie.
Ann Biol Clin (Paris). 2017 Jun 1;75(3):293-304. doi: 10.1684/abc.2017.1244.
The interactions between fatty acids (FA) classes: polyunsaturated (PUFA-ω6, PUFA-ω3), saturated (SFA), EPA (eicosapentaenoic acid-ω3), DHA (docosahexaenoic-ω3) and cardiometabolic syndrome (CMS) clusters, thrombosis development and vascular inflammation are subtle. This relationship is mediated by insulin resistance (IR), endothelial dysfunction, platelet aggregation disorder and atherosclerosis.
We investigated whether PUFA/SFA - PUFA-ω6/PUFA-ω3 ratios and EPA + DHA can be associated with predictive atherothrombogenic biomarkers status in type 2 diabetes (T2D) patients with or without hypertension (HT). The study was conducted on 507 adult subjects (men and women) cohort (36-54 years), divided into 3 groups: T2D, diabetic-hypertensive (DH) and healthy group. Patients were phenotyped regarding their CMS profile using the NCEP/ATPIII criteria. Hypertension was defined as systolic (SBP) and diastolic (DBP) blood pressure ≥140/90 mmHg, respectively. Insulin resistance was assessed by Homa-IR model. Metabolic, atherothrombogenic and inflammatory parameters (CRP) were analyzed by various automata; Non-esterified fatty acids (NEFA) by microfluorimetry; PUFA-ω6 and PUFA-ω3 by gas phase chromatography. CMS clusters and IR were found in T2D and DH groups. Dyslipidemia was correlated with accretion NEFA levels. The PUFA/SFA ratio and PUFA-ω3 level are decreased, concomitant with an increase ApoB/ApoA1 ratio and very high lipoprotein (a) concentrations. Raising the PUFA-ω6/PUFA-ω3 ratio and PUFA-ω6 levels were associated with the drop HDL-c/LDL-c ratio and EPA+DHA drastic depletion. In conclusion, fatty acids nutritional quality may be associated with atherothrombogenic biomarkers, mainly Lp (a), to prevent the thrombosis and an accident vascular risk in diabetic-hypertensive subjects.
脂肪酸（FA）类别之间的相互作用：多不饱和脂肪酸（PUFA-ω6、PUFA-ω3）、饱和脂肪酸（SFA）、二十碳五烯酸（EPA-ω3）、二十二碳六烯酸（DHA-ω3）与心脏代谢综合征（CMS）集群、血栓形成发展和血管炎症之间的关系很微妙。这种关系由胰岛素抵抗（IR）、内皮功能障碍、血小板聚集紊乱和动脉粥样硬化介导。
我们研究了PUFA/SFA - PUFA-ω6/PUFA-ω3比值以及EPA + DHA是否与有或无高血压（HT）的2型糖尿病（T2D）患者的动脉粥样硬化血栓形成预测生物标志物状态相关。该研究针对507名成年受试者（男性和女性）队列（36 - 54岁）进行，分为3组：T2D组、糖尿病合并高血压（DH）组和健康组。使用NCEP/ATPIII标准对患者的CMS概况进行表型分析。高血压分别定义为收缩压（SBP）和舒张压（DBP）≥140/90 mmHg。通过Homa-IR模型评估胰岛素抵抗。通过各种自动分析仪分析代谢、动脉粥样硬化血栓形成和炎症参数（CRP）；通过微荧光法分析非酯化脂肪酸（NEFA）；通过气相色谱法分析PUFA-ω6和PUFA-ω3。在T2D组和DH组中发现了CMS集群和IR。血脂异常与NEFA水平升高相关。PUFA/SFA比值和PUFA-ω3水平降低，同时ApoB/ApoA1比值和极高脂蛋白（a）浓度增加。提高PUFA-ω6/PUFA-ω3比值和PUFA-ω6水平与HDL-c/LDL-c比值下降和EPA + DHA急剧消耗有关。总之，脂肪酸的营养质量可能与动脉粥样硬化血栓形成生物标志物有关，主要是Lp（a），以预防糖尿病合并高血压患者的血栓形成和血管意外风险。
