铁储备与遗传性血色素沉着症基因（HFE）基因型与缺血性中风风险增加无关。一项前瞻性巢式病例对照研究。

Iron stores and HFE genotypes are not related to increased risk of ischemic stroke. A prospective nested case-referent study.

作者信息

Ekblom Kim, Hultdin Johan, Stegmayr Birgitta, Johansson Ingegerd, Van Guelpen Bethany, Hallmans Goran, Weinehall Lars, Johansson Lars, Wiklund Per-Gunnar, Marklund Stefan L

机构信息

Clinical Chemistry, Department of Medical Biosciences, Umeå University, Umeå, Sweden.

出版信息

Cerebrovasc Dis. 2007;24(5):405-11. doi: 10.1159/000108429. Epub 2007 Sep 18.

DOI:10.1159/000108429

PMID:17878720

Abstract

BACKGROUND

High iron levels can increase the formation of noxious oxygen radicals, which are thought to contribute to cerebrovascular disease. The aim of this prospective study was to determine if iron status and HFE genotypes constitute risk factors for stroke.

METHODS

First-ever stroke cases (231 ischemic and 42 hemorrhagic) and matched double referents from the population-based Northern Sweden cohorts were studied in a nested case-referent setting.

RESULTS

For total iron binding capacity, an increased risk of ischemic stroke was seen in the highest quartile (OR 1.80; 95% CI 1.14-2.83; p for trend 0.012). The highest quartile of transferrin iron saturation showed a decreased risk of ischemic stroke in men (OR 0.44; 95% CI 0.22-0.87; p for trend 0.028), but not in women. There was an increased risk of hemorrhagic stroke in the second (OR 4.07; 95% CI 1.09-15.20) and third quartile (OR 4.22; 95% CI 1.08-16.42) of ferritin. Neither quartiles of plasma iron concentrations nor the HFE C282Y and H63D genotypes were associated with ischemic or hemorrhagic stroke.

CONCLUSIONS

Iron stores were not positively related to increased risk of ischemic stroke. Furthermore, HFE genotypes did not influence the risk of ischemic or hemorrhagic stroke.

摘要

背景

高铁水平可增加有害氧自由基的形成，而有害氧自由基被认为与脑血管疾病有关。这项前瞻性研究的目的是确定铁状态和HFE基因型是否构成中风的危险因素。

方法

在基于人群的瑞典北部队列中，对首次发生的中风病例（231例缺血性中风和42例出血性中风）以及匹配的双重对照者进行了巢式病例对照研究。

结果

对于总铁结合力，在最高四分位数中缺血性中风风险增加（比值比1.80；95%置信区间1.14 - 2.83；趋势p值0.012）。转铁蛋白铁饱和度的最高四分位数显示男性缺血性中风风险降低（比值比0.44；95%置信区间0.22 - 0.87；趋势p值0.028），但女性未出现此情况。铁蛋白的第二个（比值比4.07；95%置信区间1.09 - 15.20）和第三个四分位数中出血性中风风险增加（比值比4.22；95%置信区间1.08 - 16.42）。血浆铁浓度的四分位数以及HFE C282Y和H63D基因型均与缺血性或出血性中风无关。