Clinical Chemistry, Department of Medical Biosciences, Umeå University, Umeå, Sweden.
Int J Cardiol. 2011 Jul 15;150(2):169-72. doi: 10.1016/j.ijcard.2010.04.001. Epub 2010 May 5.
Our objectives were to study the relationship between iron stores, HFE genotypes and the risk for first-ever myocardial infarction.
First-ever myocardial infarction cases (n=618) and double matched referents from the Northern Sweden Health and Disease Cohort Study were studied in a prospective nested case-referent setting. Plasma iron, total iron binding capacity, transferrin iron saturation and ferritin were analyzed, as well as several confounders. HFE C282Y and H63D genotypes were determined.
There was an inverse risk association for myocardial infarction in the highest quartiles of iron (OR 0.68; 95% CI 0.48-0.96) and transferrin iron saturation (OR 0.62; 95% CI 0.42-0.89) in men. This association, however, was lost after adjusting for C-reactive protein. Women homozygous for H63D had a higher risk for myocardial infarction.
No risk association between high iron stores and first-ever myocardial infarction was found. The higher risk in female H63D homozygotes is probably not related to iron metabolism.
本研究旨在探讨铁储存、HFE 基因型与首次心肌梗死风险之间的关系。
在前瞻性巢式病例对照研究中，我们对来自瑞典北部健康与疾病队列研究的首次心肌梗死病例（n=618）及其双重匹配对照进行了研究。分析了血浆铁、总铁结合力、转铁蛋白铁饱和度和铁蛋白，以及一些混杂因素。还确定了 HFE C282Y 和 H63D 基因型。
在男性中，铁和转铁蛋白铁饱和度最高四分位数与心肌梗死呈负相关（OR 0.68；95%CI 0.48-0.96）。然而，这种相关性在调整 C 反应蛋白后消失了。女性 H63D 纯合子发生心肌梗死的风险更高。
我们未发现高铁储存与首次心肌梗死之间存在风险关联。女性 H63D 纯合子的更高风险可能与铁代谢无关。
