Loizzi V, Cormio G, Vicino M, Selvaggi L
Division of Gynecology Oncology, Department of Obstetrics Gynecology and Neonatology, University of Bari, Bari, Italy.
Gynecol Obstet Invest. 2008;65(2):96-103. doi: 10.1159/000108600. Epub 2007 Sep 19.
Although the incidence of cervical cancer has declined in both North America and Europe, it still represents the second most common cancer in women and the fifth most common malignancy worldwide. Most patients in the developed countries present with disease either confined to the cervix or with limited extension beyond it. Historically, the standard treatment was usually radiotherapy or radical hysterectomy with node dissection. In 1999, five randomized clinical trials performed by the Gynecologic Oncology Group, the Radiation Therapy Oncology Group and the Southwest Oncology Group have demonstrated a significant outcome advantage when cisplatin-based chemotherapy was administered during radiation in patients with cervical cancer. In the current review, we will analyze the role of neoadjuvant chemotherapy followed by radiotherapy and surgery as an alternative option treatment to the standard chemoradiation for locally advanced cervical cancer (stage Ib2 or larger).
尽管北美和欧洲的宫颈癌发病率均有所下降，但它仍是女性第二常见的癌症，也是全球第五大常见恶性肿瘤。发达国家的大多数患者所患疾病要么局限于宫颈，要么仅稍有超出宫颈的扩散。从历史上看，标准治疗通常是放射疗法或根治性子宫切除术加淋巴结清扫术。1999年，妇科肿瘤学组、放射治疗肿瘤学组和西南肿瘤学组进行的五项随机临床试验表明，宫颈癌患者在放疗期间给予以顺铂为基础的化疗时，会有显著的疗效优势。在当前这篇综述中，我们将分析新辅助化疗后再进行放疗和手术作为局部晚期宫颈癌（Ib2期或更严重分期）标准放化疗替代治疗方案的作用。
