Zhang Daqing, Che Dongfang, Zhao Shuiping, Sun Yingxian
Department of Cardiology, Shengjing Hospital affiliated to China Medical University, Shenyang, Liaoning, PR China.
J Cardiovasc Pharmacol. 2007 Sep;50(3):281-5. doi: 10.1097/FJC.0b013e3180950248.
C-reactive protein (CRP) is a powerful predictor for coronary heart diseases. Recent study has revealed that adipocytes can produce CRP. Peroxisome proliferator-activated receptor (PPAR) gamma, an important nuclear transcriptional factor, can be predominately detected in adipocytes and exert several biological properties, including antiinflammatory effects. The authors investigated the effects of 2-week atorvastatin treatment on CRP secretions by adipocytes in hypercholesterolemic rabbits. CRP concentrations in serum and adipocytes culture supernatants were measured by latex particle-enhanced immunoturbidometric method. RT-PCR was used to evaluate PPARgamma mRNA expression. Two weeks of atorvastatin treatment resulted in significant reductions of circulating CRP concentrations, which were associated with CRP secretions in adipocytes (r = 0.688, P = 0.007). Meanwhile, CRP secretions in adipocytes were intimately related to low-density lipoprotein (LDL) cholesterol levels (r = 0.869, P < 0.001) and PPARgamma mRNA expressions in adipocytes (r = -0.857, P < 0.001). These data demonstrate that hypercholesterolemia may induce CRP secretions in adipocytes; short-term atorvastatin treatment reduces CRP secretions in adipocytes, possibly through lowering blood cholesterol levels and upregulating PPARgamma expressions in adipocytes. These findings enrich the pharmacological effects of statins and also enlighten the relationship between adipocytes and hypercholesterolemia.
C反应蛋白（CRP）是冠心病的有力预测指标。最近的研究表明，脂肪细胞能够产生CRP。过氧化物酶体增殖物激活受体（PPAR）γ是一种重要的核转录因子，主要在脂肪细胞中被检测到，并具有多种生物学特性，包括抗炎作用。作者研究了阿托伐他汀治疗2周对高胆固醇血症兔脂肪细胞CRP分泌的影响。采用乳胶颗粒增强免疫比浊法测定血清和脂肪细胞培养上清液中的CRP浓度。用逆转录聚合酶链反应（RT-PCR）评估PPARγ mRNA的表达。阿托伐他汀治疗2周导致循环CRP浓度显著降低，这与脂肪细胞中CRP的分泌相关（r = 0.688，P = 0.007）。同时，脂肪细胞中CRP的分泌与低密度脂蛋白（LDL）胆固醇水平密切相关（r = 0.869，P < 0.001）以及脂肪细胞中PPARγ mRNA的表达密切相关（r = -0.857，P < 0.001）。这些数据表明，高胆固醇血症可能诱导脂肪细胞分泌CRP；短期阿托伐他汀治疗可降低脂肪细胞中CRP的分泌，可能是通过降低血胆固醇水平和上调脂肪细胞中PPARγ的表达来实现的。这些发现丰富了他汀类药物的药理作用，也揭示了脂肪细胞与高胆固醇血症之间的关系。
