Lin Li-Li, Liu Ai-Jun, Liu Jian-Guo, Yu Xue-Hong, Qin Lu-Ping, Su Ding-Feng
Department of Pharmacology, Second Military Medical University, Shanghai, China.
J Cardiovasc Pharmacol. 2007 Sep;50(3):327-32. doi: 10.1097/FJC.0b013e3180cbd0e7.
Scutellarin is an active molecule existing in Erigeron breviscapus (vant.) Hand-Mazz. The present work was designed to study the antiischemic effects of scutellarin and its mixture with another substance, breviscapine, in male Sprague-Dawley (SD) rats. Ligature of left anterior descending arteries was performed to induce acute myocardial infarction (MI), and the middle cerebral artery occlusion was created to induce focal cerebral ischemia. The MI size was significantly reduced by scutellarin (15 and 50 mg/kg) but not by breviscapine (5 to 50 mg/kg); the effect of scutellarin on the anti-MI was dose-dependent. Compared with control group, scutellarin (50 mg/kg) reduced the myocardium cell apoptosis in MI rats. The two drugs together (5 to 50 mg/kg) significantly reduced infarction size in focal brain ischemic rats (P < 0.05). There were no significant differences among the 3 dosages in breviscapine-treated rats, and the effect of scutellarin on the anticerebral ischemia was dose-dependent. The results demonstrate that the protective effects of scutellarin on cardiovascular and cerebrovascular ischemia were better than its mixture, breviscapine, in rats.
灯盏花素是一种存在于短葶飞蓬（Erigeron breviscapus (vant.) Hand-Mazz.）中的活性分子。本研究旨在探讨灯盏花素及其与另一种物质灯盏花乙素的混合物对雄性Sprague-Dawley（SD）大鼠的抗缺血作用。通过结扎左冠状动脉前降支诱导急性心肌梗死（MI），并通过大脑中动脉闭塞诱导局灶性脑缺血。灯盏花素（15和50 mg/kg）可显著减小MI面积，但灯盏花乙素（5至50 mg/kg）则无此作用；灯盏花素的抗MI作用呈剂量依赖性。与对照组相比，灯盏花素（50 mg/kg）可减少MI大鼠心肌细胞凋亡。两种药物联合使用（5至50 mg/kg）可显著减小局灶性脑缺血大鼠的梗死面积（P < 0.05）。灯盏花乙素治疗组的3个剂量之间无显著差异，灯盏花素的抗脑缺血作用呈剂量依赖性。结果表明，在大鼠中，灯盏花素对心血管和脑血管缺血的保护作用优于其混合物灯盏花乙素。
