缺氧培养条件下早期肝细胞癌中Survivin的表达及抗癌药物治疗后的情况。
Survivin expression in early hepatocellular carcinoma and post-treatment with anti-cancer drug under hypoxic culture condition.
作者信息
Mamori Satoshi, Asakura Tadashi, Ohkawa Kiyoshi, Tajiri Hisao
机构信息
Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan.
出版信息
World J Gastroenterol. 2007 Oct 28;13(40):5306-11. doi: 10.3748/wjg.v13.i40.5306.
Abstract
AIM
To investigate the expression of survivin during the early stages of hepatocellular carcinoma (HCC).
METHODS
Immunohistochemical expression of survivin in liver tumor and non-tumor tissue specimens taken from 17 patients was compared. In addition, to determine the survivin expression in response to anti-cancer drugs in early stage HCC, the survivin expression was determined after the treatment of the HCC cells with anti-cancer drugs under hypoxic culture conditions.
RESULTS
Survivin proteins were expressed in 64.7% of cells in early HCC specimens. A correlation between the survivin expression rate in the peritumoral hepatocytes and the rate of expression in the HCC specimens (low-rate group vs high-rate group) was observed. The survivin protein concentration in HCC cells was increased by the combination of hypoxia and anti-cancer drugs.
CONCLUSION
This study suggests that survivin could be used as a therapeutic target in early HCC.
摘要
目的
研究生存素在肝细胞癌（HCC）早期阶段的表达情况。
方法
比较了取自17例患者的肝肿瘤和非肿瘤组织标本中生存素的免疫组化表达。此外，为了确定早期HCC中抗癌药物作用下生存素的表达情况，在缺氧培养条件下用抗癌药物处理HCC细胞后测定生存素表达。
结果
早期HCC标本中64.7%的细胞表达生存素蛋白。观察到肿瘤周围肝细胞中生存素表达率与HCC标本中表达率（低表达组与高表达组）之间存在相关性。缺氧与抗癌药物联合使用可增加HCC细胞中生存素蛋白浓度。
结论
本研究表明生存素可作为早期HCC的治疗靶点。
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2
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