Mamori Satoshi, Asakura Tadashi, Ohkawa Kiyoshi, Tajiri Hisao
Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan.
World J Gastroenterol. 2007 Oct 28;13(40):5306-11. doi: 10.3748/wjg.v13.i40.5306.
To investigate the expression of survivin during the early stages of hepatocellular carcinoma (HCC).
Immunohistochemical expression of survivin in liver tumor and non-tumor tissue specimens taken from 17 patients was compared. In addition, to determine the survivin expression in response to anti-cancer drugs in early stage HCC, the survivin expression was determined after the treatment of the HCC cells with anti-cancer drugs under hypoxic culture conditions.
Survivin proteins were expressed in 64.7% of cells in early HCC specimens. A correlation between the survivin expression rate in the peritumoral hepatocytes and the rate of expression in the HCC specimens (low-rate group vs high-rate group) was observed. The survivin protein concentration in HCC cells was increased by the combination of hypoxia and anti-cancer drugs.
This study suggests that survivin could be used as a therapeutic target in early HCC.
研究生存素在肝细胞癌（HCC）早期阶段的表达情况。
比较了取自17例患者的肝肿瘤和非肿瘤组织标本中生存素的免疫组化表达。此外，为了确定早期HCC中抗癌药物作用下生存素的表达情况，在缺氧培养条件下用抗癌药物处理HCC细胞后测定生存素表达。
早期HCC标本中64.7%的细胞表达生存素蛋白。观察到肿瘤周围肝细胞中生存素表达率与HCC标本中表达率（低表达组与高表达组）之间存在相关性。缺氧与抗癌药物联合使用可增加HCC细胞中生存素蛋白浓度。
本研究表明生存素可作为早期HCC的治疗靶点。
