Dai Yi, Shen Lin, Yang Yan-ping
Department of Orthopaedics and Trauma, Union Hospital of Tongji Medical College, Huazhong Science and Technology University, Wuhan .
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Aug;27(8):696-9.
To study the effects of Migu Tablet (MGT) on bone mineral density (BMD), serum levels of osteoprotegerin (OPG) and its ligand (OPGL), and bone metabolic markers in patients with postmenopausal osteoporosis (PMO).
BMD in 192 women of natural menopause, 48 to 65 years old, were determined. Among them, 160 women with PMO were randomized into 4 groups, 54 in the Migu Tablet group (MGTG), 53 in the Xianlin Gubao group (XLGBG) and 53 in the Leli Calcium group (LCG). And the other 32 women with BMD in normal range were set as the control group. Serum levels of OPG, OPGL, bone alkaline phosphates (sBAP), osteocalcin (sOC), cross-linked C-telopeptides of collagen type I (sCTx), and urine level of bone cross-linked N-telopeptides of collagen type I (uNTx) were measured before treatment and at the 12th and 24th week of treatment, with enzyme-linked immunosorbent assay (ELISA); BMD of orthophoric lumbar vertebrae, femoral neck, Ward's triangle and trochanter were determined by dual-energy X-ray absorptiometry at the same time as well.
After 24-week treatment, BMD was heightened to different degree, serum levels of OPG, sCTx, uNTx/Cr were significantly decreased and OPGL, sBAP, sOC were increased in the MGTG and XLGBG, while these indexes showed insignificant change in the LCG and the control group.
The effect of MGT in treating PMO were notable, just like that of XLGB, but single medication of calcium tablet cannot alleviate the disease and also incapable to prevent the loss of bone.
研究密骨片（MGT）对绝经后骨质疏松症（PMO）患者骨密度（BMD）、血清骨保护素（OPG）及其配体（OPGL）水平以及骨代谢标志物的影响。
测定192例48至65岁自然绝经女性的骨密度。其中，160例PMO女性被随机分为4组，密骨片组（MGTG）54例，仙灵骨葆组（XLGBG）53例，乐力钙组（LCG）53例。另外32例骨密度在正常范围的女性作为对照组。治疗前及治疗第12周和第24周采用酶联免疫吸附测定（ELISA）法检测血清OPG、OPGL、骨碱性磷酸酶（sBAP）、骨钙素（sOC）、Ⅰ型胶原交联C末端肽（sCTx）水平以及尿Ⅰ型胶原交联N末端肽（uNTx）水平；同时采用双能X线吸收法测定正位腰椎、股骨颈、Ward三角和大转子的骨密度。
治疗24周后，MGTG组和XLGBG组骨密度不同程度升高，血清OPG、sCTx、uNTx/Cr水平显著降低，OPGL、sBAP、sOC水平升高，而LCG组和对照组这些指标变化不明显。
密骨片治疗PMO效果显著，与仙灵骨葆类似，但单纯服用钙片不能缓解病情，也无法预防骨质流失。
