Dai Yi, Shen Lin
Department of Traditional Chinese Medicine, Union Hospital of Huazhong Science and Technology University, Wuhan 430022, China.
Zhongguo Zhong Yao Za Zhi. 2007 Nov;32(22):2409-12.
To study the effects of Migu tablet(MG) on bone mineral density (BMD), serum matrix metalloproteinase-2 (MMP-2) and bone metabolic markers in Chinese postmenopausal women.
According to the criteria of osteoporosis, 192 Chinese postmenopausal female of the aged 55-62 were randomized into 4 groups, such as the normal, MG group, XLGB group and Leli group. The serum MMP-2, bone alkaline phosphates (sBAP), osteocalcin (sOC), bone cross-linked C-telopeptides of type I collagen (sCTx) and urine bone cross-linked N-telopeptides of type I collagen (uNTx) were measured using ELISA. BMD were measured using dual energy X-ray absorptiometry before and after medication at 12 and 24 weeks.
After treatment, the values of BMD were significantly higher in MG and XLGB groups separately, otherwise lower in Leli and normal control groups. At the same time, serum MMP-2, sCTx, uNTx/Cr concentrations were significantly lower and sBAP, sOC concentrations were higher, but the concentrations in Leli and normal control groups were basically same to the value of before treatment.
The effects of MG tablet to treat the PMO were notable, just same to XLGB. But calcium tablet cannot play a role in the treatment of osteoporosis and do not prevent the loss of bone.
研究密骨片（MG）对中国绝经后女性骨密度（BMD）、血清基质金属蛋白酶-2（MMP-2）及骨代谢标志物的影响。
根据骨质疏松症标准，将192例年龄在55 - 62岁的中国绝经后女性随机分为4组，即正常组、密骨片组、仙灵骨葆组和乐力组。采用酶联免疫吸附测定法（ELISA）检测血清MMP-2、骨碱性磷酸酶（sBAP）、骨钙素（sOC）、I型胶原交联C末端肽（sCTx）及尿I型胶原交联N末端肽（uNTx）。在用药12周和24周前后，使用双能X线吸收法测量骨密度。
治疗后，密骨片组和仙灵骨葆组的骨密度值分别显著升高，而乐力组和正常对照组则降低。同时，血清MMP-2、sCTx、uNTx/Cr浓度显著降低，sBAP、sOC浓度升高，但乐力组和正常对照组的浓度与治疗前基本相同。
密骨片治疗绝经后骨质疏松症（PMO）的效果显著，与仙灵骨葆相同。但钙片在治疗骨质疏松症中不能发挥作用，也不能预防骨质流失。
