Itomi Seiko, Okumura Akihisa, Ikuta Taketo, Suzuki Yoshiko, Kato Toru, Negoro Tamiko, Watanabe Kazuyoshi
Department of Pediatrics, Nagoya First Red Cross Hospital, Nagoya, Aichi.
No To Hattatsu. 2007 Sep;39(5):356-9.
This study aimed to clarify factors associated with intravenous administered phenytoin-induced hypersensitivity reaction. The incidence of hypersensitivity was significantly more frequent in boys than in girls (P < 0.05). Patients with hypersensitivity were relatively younger than those without hypersensitivity, although the difference was not statistically significant. There was no relation between the initial dose or maximum blood level of phenytoin and the occurrence of hypersensitivity. The initial serum level of phenytoin was significantly lower in patients with hypersensitivity than in those without hypersensitivity (P < 0.05), whereas the total dose of phenytoin was relatively larger in patients with hypersensitivity than those without. Reactivation of human herpes virus-6 was not recognized in all 3 patients in whom virological examination was performed using real-time polymerase chain reaction.
本研究旨在阐明与静脉注射苯妥英钠引起的过敏反应相关的因素。过敏反应的发生率在男孩中显著高于女孩（P<0.05）。过敏患者相对未过敏患者年龄更小，尽管差异无统计学意义。苯妥英钠的初始剂量或最高血药浓度与过敏反应的发生无关。过敏患者的苯妥英钠初始血清浓度显著低于未过敏患者（P<0.05），而过敏患者的苯妥英钠总剂量相对高于未过敏患者。在所有3例采用实时聚合酶链反应进行病毒学检查的患者中均未发现人疱疹病毒6型再激活。
