Bodini A, D'Orazio C, Peroni D G, Corradi M, Zerman L, Folesani G, Assael B M, Boner A L, Piacentini G L
Dipartimento di Pediatria, Università di Verona, Verona, Italy.
Int J Immunopathol Pharmacol. 2007 Jul-Sep;20(3):467-72. doi: 10.1177/039463200702000305.
Interleukin (IL)-8 is a major factor in inflammatory response and the IL-8 levels in exhaled breath condensate (EBC) may be used as a marker of airway inflammation. Airway acidification is implicated in the pathophysiology of obstructive airway diseases and pH EBC values have been used as a marker of airway acidification. The aim of our study is to investigate whether IL-8 and pH levels in EBC of cystic fibrosis (CF) children with respiratory exacerbations change after antibiotic treatment. Lung function, IL-8 and pH EBC values were measured in fifteen CF children (mean age 11 years) with acute exacerbation before (T0) and after two weeks (T1) of antibiotic treatment. IL-8 and pH values were compared by paired t-test. A p less than 0.05 was considered significant. IL-8 EBC levels decreased after antibiotic treatment (T0 0.36+/-0.03pg/ml vs T1 0.28+/-0.03pg/ml; p=0.03) and pH values increased (T0 7.36+/-0.09 vs T1 7.61+/-0.08; p=0.04). Results suggest possible application of EBC as a non-invasive tool to monitor efficacy of antibiotic treatment in CF patients.
白细胞介素（IL）-8是炎症反应中的一个主要因素，呼出气冷凝液（EBC）中的IL-8水平可用作气道炎症的标志物。气道酸化与阻塞性气道疾病的病理生理学有关，EBC的pH值已被用作气道酸化的标志物。我们研究的目的是调查抗生素治疗后，患有呼吸加重的囊性纤维化（CF）儿童EBC中的IL-8和pH水平是否会发生变化。对15名患有急性加重的CF儿童（平均年龄11岁）在抗生素治疗前（T0）和治疗两周后（T1）测量肺功能、IL-8和EBC的pH值。通过配对t检验比较IL-8和pH值。p值小于0.05被认为具有统计学意义。抗生素治疗后，EBC中的IL-8水平下降（T0为0.36±0.03pg/ml，T1为0.28±0.03pg/ml；p = 0.03），pH值升高（T0为7.36±0.09，T1为7.61±0.08；p = 0.04）。结果表明，EBC有可能作为一种非侵入性工具，用于监测CF患者抗生素治疗的疗效。
