Department of Critical Care Medicine, University of Pittsburgh, 642A Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA.
Curr Infect Dis Rep. 2007 Sep;9(5):382-6. doi: 10.1007/s11908-007-0059-3.
Long-term mortality following severe sepsis is high, and fewer than half of patients who experience severe sepsis are alive at 1 year. Mechanisms underlying increased long-term mortality remain poorly understood. Animal and human studies suggest that abnormalities of the innate immune system may contribute to increased long-term mortality. This review article examines the epidemiology and potential mechanisms underlying long-term outcomes from sepsis and challenges to conducting long-term outcome studies in the critically ill.
严重脓毒症患者的长期死亡率很高，仅有不到一半的严重脓毒症患者在 1 年内存活。导致长期死亡率增加的机制仍知之甚少。动物和人类研究表明，固有免疫系统的异常可能导致长期死亡率增加。本文综述了脓毒症长期结局的流行病学和潜在机制，以及危重病患者进行长期结局研究面临的挑战。
