保留突触α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体
Retaining synaptic AMPARs.
作者信息
Jaskolski Frédéric, Martin Stéphane, Henley Jeremy M
机构信息
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK.
出版信息
Neuron. 2007 Sep 20;55(6):825-7. doi: 10.1016/j.neuron.2007.09.004.
Abstract
Endocytosis, exocytosis, and lateral diffusion are key mechanisms for AMPA receptor trafficking. Endocytosis of AMPARs and other postsynaptic proteins has been proposed to occur at specific endocytic zones (EZs), but the mechanisms that regulate this process are not at all clear. In this issue of Neuron, Lu et al. show that correct synaptic EZ positioning requires links between the GTPase dynamin-3 and the Homer/Shank complex.
摘要
内吞作用、胞吐作用和侧向扩散是AMPA受体转运的关键机制。AMPA受体及其他突触后蛋白的内吞作用被认为发生在特定的内吞区（EZs），但调节这一过程的机制尚不清楚。在本期《神经元》杂志中，卢等人表明，正确的突触EZ定位需要GTP酶发动蛋白3与Homer/Shank复合体之间的联系。
相似文献
1
Retaining synaptic AMPARs.保留突触α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体
Neuron. 2007 Sep 20;55(6):825-7. doi: 10.1016/j.neuron.2007.09.004.
2
Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer.通过发动蛋白-3与Homer的物理偶联实现内吞区的突触后定位和AMPA受体循环。
Neuron. 2007 Sep 20;55(6):874-89. doi: 10.1016/j.neuron.2007.06.041.
3
Endocytic trafficking and recycling maintain a pool of mobile surface AMPA receptors required for synaptic potentiation.内吞运输和再循环维持着突触增强所需的可移动表面AMPA受体池。
Neuron. 2009 Jul 16;63(1):92-105. doi: 10.1016/j.neuron.2009.05.025.
4
Endocytosis of neurotransmitter receptors: location matters.神经递质受体的内吞作用：位置至关重要。
Cell. 2007 Sep 21;130(6):988-9. doi: 10.1016/j.cell.2007.09.006.
5
The X-linked mental retardation protein OPHN1 interacts with Homer1b/c to control spine endocytic zone positioning and expression of synaptic potentiation.X 连锁精神发育迟滞蛋白 OPHN1 与 Homer1b/c 相互作用，控制脊柱内吞区的定位和突触增强表达。
J Neurosci. 2014 Jun 25;34(26):8665-71. doi: 10.1523/JNEUROSCI.0894-14.2014.
6
Dynamin-dependent endocytosis of ionotropic glutamate receptors.离子型谷氨酸受体的发动蛋白依赖性内吞作用。
Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14112-7. doi: 10.1073/pnas.96.24.14112.
7
Ischemic insults direct glutamate receptor subunit 2-lacking AMPA receptors to synaptic sites.缺血性损伤将缺乏谷氨酸受体亚基2的AMPA受体导向突触位点。
J Neurosci. 2006 May 17;26(20):5309-19. doi: 10.1523/JNEUROSCI.0567-06.2006.
8
Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs.突触外AMPA受体的短暂内吞作用先于AMPA受体（AMPARs）从突触中移除。
J Neurosci. 2004 Jun 2;24(22):5172-6. doi: 10.1523/JNEUROSCI.1042-04.2004.
9
Modeling the role of lateral membrane diffusion in AMPA receptor trafficking along a spiny dendrite.模拟AMPA受体沿棘状树突运输过程中侧向膜扩散的作用。
J Comput Neurosci. 2008 Oct;25(2):366-89. doi: 10.1007/s10827-008-0084-8. Epub 2008 Mar 5.
10
Spatial and Temporal Regulation of Receptor Endocytosis in Neuronal Dendrites Revealed by Imaging of Single Vesicle Formation.通过单囊泡形成成像揭示神经元树突中受体胞吞作用的时空调节
Cell Rep. 2017 Feb 21;18(8):1840-1847. doi: 10.1016/j.celrep.2017.01.081.
引用本文的文献
1
Role of glycine receptors in glycine-induced LTD in hippocampal CA1 pyramidal neurons.甘氨酸受体在海马 CA1 锥体神经元中甘氨酸诱导 LTD 中的作用。
Neuropsychopharmacology. 2011 Aug;36(9):1948-58. doi: 10.1038/npp.2011.86. Epub 2011 May 18.
2
Hormonal regulation of AMPA receptor trafficking and memory formation.激素对 AMPA 受体转运和记忆形成的调节。
Front Synaptic Neurosci. 2009 Oct 13;1:2. doi: 10.3389/neuro.19.002.2009. eCollection 2009.
3
Synaptic receptor trafficking: the lateral point of view.突触受体转运：侧向视角
Neuroscience. 2009 Jan 12;158(1):19-24. doi: 10.1016/j.neuroscience.2008.01.075. Epub 2008 Feb 16.
本文引用的文献
1
Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer.通过发动蛋白-3与Homer的物理偶联实现内吞区的突触后定位和AMPA受体循环。
Neuron. 2007 Sep 20;55(6):874-89. doi: 10.1016/j.neuron.2007.06.041.
2
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking.Arc/Arg3.1与内吞机制相互作用以调节AMPA受体的转运。
Neuron. 2006 Nov 9;52(3):445-59. doi: 10.1016/j.neuron.2006.08.033.
3
Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane.外泌体在AMPA受体靶向和插入突触后膜中的双重作用。
EMBO J. 2006 Apr 19;25(8):1623-34. doi: 10.1038/sj.emboj.7601065. Epub 2006 Apr 6.
4
A dynamin-3 spliced variant modulates the actin/cortactin-dependent morphogenesis of dendritic spines.发动蛋白3剪接变体调节肌动蛋白/皮层肌动蛋白依赖性树突棘形态发生。
J Cell Sci. 2005 Mar 15;118(Pt 6):1279-90. doi: 10.1242/jcs.01711. Epub 2005 Mar 1.
5
Lateral organization of endocytic machinery in dendritic spines.树突棘中内吞机制的侧向组织
Nat Neurosci. 2004 Sep;7(9):917-8. doi: 10.1038/nn1303. Epub 2004 Aug 22.
6
Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs.突触外AMPA受体的短暂内吞作用先于AMPA受体（AMPARs）从突触中移除。
J Neurosci. 2004 Jun 2;24(22):5172-6. doi: 10.1523/JNEUROSCI.1042-04.2004.
7
The dynamin superfamily: universal membrane tubulation and fission molecules?发动蛋白超家族：通用的膜成管和裂变分子？
Nat Rev Mol Cell Biol. 2004 Feb;5(2):133-47. doi: 10.1038/nrm1313.
8
Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer.发动蛋白3是突触后膜的一个组成部分，在那里它与代谢型谷氨酸受体5（mGluR5）和亲代谢型谷氨酸受体结合蛋白（Homer）相互作用。
Curr Biol. 2003 Mar 18;13(6):510-5. doi: 10.1016/s0960-9822(03)00136-2.
9
Dynamics and regulation of clathrin coats at specialized endocytic zones of dendrites and spines.树突和棘突特化内吞区域网格蛋白衣被的动力学及调控
Neuron. 2002 Oct 24;36(3):435-49. doi: 10.1016/s0896-6273(02)00979-0.
10
Regulation of dendritic spine morphology and synaptic function by Shank and Homer.Shank和Homer对树突棘形态和突触功能的调控
Neuron. 2001 Jul 19;31(1):115-30. doi: 10.1016/s0896-6273(01)00339-7.
Zotero 插件