专业抗原呈递细胞中组织蛋白酶的受体介导靶向作用。
Receptor-mediated targeting of cathepsins in professional antigen presenting cells.
作者信息
Hillaert Ulrik, Verdoes Martijn, Florea Bogdan I, Saragliadis Athanasios, Habets Kim L L, Kuiper Johan, Van Calenbergh Serge, Ossendorp Ferry, van der Marel Gijsbert A, Driessen Christoph, Overkleeft Hermen S
机构信息
Leiden Institute of Chemistry, Leiden University, P.O. Box 9052, 2300 RA Leiden, The Netherlands.
出版信息
Angew Chem Int Ed Engl. 2009;48(9):1629-32. doi: 10.1002/anie.200805529.
Tag for professionals: A fluorescently tagged clustered mannoside DCG-04 analogue (see structure) is designed and synthesized using a modular approach. Uptake of the probe in professional antigen presenting cells and subsequent labeling of cathepsins proceeded in a mannose-receptor dependent manner.
专业人士标签
采用模块化方法设计并合成了一种荧光标记的簇状甘露糖苷DCG-04类似物（见结构）。该探针在专业抗原呈递细胞中的摄取以及随后组织蛋白酶的标记以甘露糖受体依赖性方式进行。
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