Na Hyun Sik, Hong Su Jin, Yoon Hyo Joong, Maeng Joo Hee, Ko Bong Min, Jung In Sup, Ryu Chang Beom, Kim Jin Oh, Cho Joo Young, Lee Joon Seong, Lee Moon Sung, Shim Chan Sup, Kim Boo Sung
Department of Internal Medicine, Institute for Digestive Research, Soonchunhyang University School of Medicine, Bucheon and Seoul, Korea.
Korean J Gastroenterol. 2007 Sep;50(3):170-5.
BACKGROUND/AIMS: The increasing trend of antibiotic resistance emphasizes the need for the assessment of eradication rate of first and second-line therapy for Helicobacter pylori (H. pylori) infection. The reinfection rate depends on the geographical, national, or socioeconomic status of the patients. The aim of this study was to evaluate the recent 5-year changes of eradication rates and the reinfection rates after the successful eradication of Helicobacter pylori infection for 3-years follow-up in Bucheon, Korea.
From February 2001 to August 2006, 3,267 patients with H. pylori-positive peptic ulcer disease received the first-line therapy for 7 days. The 317 patients who failed to the first-line therapy received the second-line therapy for 7 days. The 167 patients with 3-years follow-up after the successful eradication were included. 13C-urea breath tests or rapid urease tests and histologies were assessed to determine the H. pylori status after the eradication.
The eradication rate of first-line therapy was 83.7% in 2001, 83.4% in 2002, 83.7% in 2003, 85.9% in 2004, 87.2% in 2005, and 81.8% in 2006 by per protocol analysis (PP), respectively. The eradication rate of second-line therapy was 80.0% in 2002, 86.8% in 2003, 89.7% in 2004, 98.0% in 2005, and 78.8% in 2006 by PP. The cumulative reinfection rate was 6.0%. The annual reinfection rate was 2.0%. The recurrence rate of peptic ulcer was 17.2% in the patients without reinfection and 50% with reinfection.
The eradication rate for H. pylori have not changed in the recent 5-years. The annual reinfection rate was low. The successful eradication of H. pylori was effective for preventing the recurrence of peptic ulcers.
背景/目的：抗生素耐药性的上升趋势凸显了评估幽门螺杆菌（H. pylori）感染一线和二线治疗根除率的必要性。再感染率取决于患者的地理、国家或社会经济状况。本研究的目的是评估韩国富川地区幽门螺杆菌感染成功根除后3年随访期间，根除率和再感染率最近5年的变化情况。
2001年2月至2006年8月，3267例幽门螺杆菌阳性消化性溃疡患者接受了为期7天的一线治疗。317例一线治疗失败的患者接受了为期7天的二线治疗。纳入167例成功根除后进行3年随访的患者。通过13C-尿素呼气试验或快速尿素酶试验以及组织学检查来确定根除后幽门螺杆菌的状态。
根据符合方案分析（PP），2001年一线治疗的根除率为83.7%，2002年为83.4%，2003年为83.7%，2004年为85.9%，2005年为87.2%，2006年为81.8%。2002年二线治疗的根除率为80.0%，2003年为86.8%，2004年为89.7%，2005年为98.0%，2006年为78.8%。累积再感染率为6.0%。年再感染率为2.0%。未再感染患者的消化性溃疡复发率为17.2%，再感染患者为50%。
最近5年幽门螺杆菌的根除率没有变化。年再感染率较低。成功根除幽门螺杆菌对预防消化性溃疡复发有效。
