来自虫草菌株BCC 16173和BCC 16176的ES - 242衍生物和环庚肽。

ES-242 derivatives and cycloheptapeptides from Cordyceps sp. strains BCC 16173 and BCC 16176.

作者信息

Isaka Masahiko, Srisanoh Urarat, Lartpornmatulee Nattapat, Boonruangprapa Tanapong

机构信息

National Center for Genetic Engineering and Biotechnology, Thailand Science Park, 113 Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.

出版信息

J Nat Prod. 2007 Oct;70(10):1601-4. doi: 10.1021/np070357h. Epub 2007 Sep 22.

DOI:10.1021/np070357h

PMID:17887724

Abstract

Five new ES-242 analogues ( 1- 5) were isolated together with nine known compounds ( 6- 14) from the insect pathogenic fungus Cordyceps sp. BCC 16173. A closely related strain, BCC 16176, provided cordyheptapeptide A ( 15) and small amount of its new analogue, cordyheptapeptide B ( 16), along with known ES-242s. Structures of the new bioxanthracenes, 1- 5, were determined to be 6'- O-desmethyl analogues of 6 (ES-242-4), 8, 9 (ES-242-2), 12, and 13, respectively, primarily by spectroscopic analyses. Cordyheptapeptide B ( 16) has an N-methyl- l-phenylalanine residue instead of the N-methyl- l-tyrosine in 15.

摘要

从昆虫病原真菌虫草菌 Cordyceps sp. BCC 16173 中分离出了 5 种新的 ES - 242 类似物（1 - 5）以及 9 种已知化合物（6 - 14）。与之密切相关的菌株 BCC 16176 除了产生已知的 ES - 242 类化合物外，还提供了虫草七肽 A（15）及其少量新类似物虫草七肽 B（16）。新的二氧杂蒽类化合物 1 - 5 的结构主要通过光谱分析确定，分别为 6（ES - 242 - 4）、8、9（ES - 242 - 2）、12 和 13 的 6'-O-去甲基类似物。虫草七肽 B（16）在 15 中具有 N - 甲基 - L - 苯丙氨酸残基而非 N - 甲基 - L - 酪氨酸残基。