Isaka Masahiko, Srisanoh Urarat, Lartpornmatulee Nattapat, Boonruangprapa Tanapong
National Center for Genetic Engineering and Biotechnology, Thailand Science Park, 113 Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.
J Nat Prod. 2007 Oct;70(10):1601-4. doi: 10.1021/np070357h. Epub 2007 Sep 22.
Five new ES-242 analogues ( 1- 5) were isolated together with nine known compounds ( 6- 14) from the insect pathogenic fungus Cordyceps sp. BCC 16173. A closely related strain, BCC 16176, provided cordyheptapeptide A ( 15) and small amount of its new analogue, cordyheptapeptide B ( 16), along with known ES-242s. Structures of the new bioxanthracenes, 1- 5, were determined to be 6'- O-desmethyl analogues of 6 (ES-242-4), 8, 9 (ES-242-2), 12, and 13, respectively, primarily by spectroscopic analyses. Cordyheptapeptide B ( 16) has an N-methyl- l-phenylalanine residue instead of the N-methyl- l-tyrosine in 15.
从昆虫病原真菌虫草菌 Cordyceps sp. BCC 16173 中分离出了 5 种新的 ES - 242 类似物（1 - 5）以及 9 种已知化合物（6 - 14）。与之密切相关的菌株 BCC 16176 除了产生已知的 ES - 242 类化合物外，还提供了虫草七肽 A（15）及其少量新类似物虫草七肽 B（16）。新的二氧杂蒽类化合物 1 - 5 的结构主要通过光谱分析确定，分别为 6（ES - 242 - 4）、8、9（ES - 242 - 2）、12 和 13 的 6'-O-去甲基类似物。虫草七肽 B（16）在 15 中具有 N - 甲基 - L - 苯丙氨酸残基而非 N - 甲基 - L - 酪氨酸残基。
