来自真菌 Xylaria sp. BCC 21097 的半日花烷型倍半萜。

Eremophilane-type sesquiterpenes from the fungus Xylaria sp. BCC 21097.

机构信息

National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.

出版信息

J Nat Prod. 2010 Apr 23;73(4):683-7. doi: 10.1021/np100030x.

DOI:10.1021/np100030x

PMID:20155932

Abstract

Seven new eremophilane-type sesquiterpenoids (1-5, 7, and 8) and the known mairetolide F (6) were isolated from the endophytic Xylaria sp. BCC 21097. A new furofurandione (9) was also isolated from the fungal extract. The structures of the new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometry data in combination with chemical reaction studies. Eremophilanolides possessing an alpha-methylene-gamma-lactone (1-3) exhibited moderate cytotoxic activities, while related analogues bearing an endo double bond (6 and 7) were inactive.

摘要

从内生真菌 Xylaria sp. BCC 21097 中分离得到了 7 种新的半日花烷型倍半萜（1-5、7 和 8）和已知的麦瑞托内酯 F（6）。还从真菌提取物中分离得到了一种新的呋喃二酮（9）。通过分析 NMR 光谱和质谱数据并结合化学反应研究，确定了新化合物的结构。具有α-亚甲基-γ-内酯（1-3）的半日花烷醇类化合物表现出中等的细胞毒性活性，而具有内双键的相关类似物（6 和 7）则没有活性。