产前酒精暴露与隐睾症
Prenatal alcohol exposure and cryptorchidism.
作者信息
Jensen M S, Bonde J P, Olsen J
机构信息
Department of Occupational Medicine, University Hospital of Aarhus, Aarhus, Denmark.
出版信息
Acta Paediatr. 2007 Nov;96(11):1681-5. doi: 10.1111/j.1651-2227.2007.00506.x. Epub 2007 Sep 19.
AIM
A recently published study reported markedly increased risk of cryptorchidism among boys whose mothers had an average gestational alcohol intake of five or more drinks per week. The aim of this study is to follow up on this finding by estimating the association between prenatal alcohol exposure and persistent cryptorchidism.
METHODS
We used prospectively collected information on prenatal exposures and obstetric information on the birth of 5716 boys, collected from 1984 to 1987. During the 16-19 years of follow-up in a nationwide patient register, 270 cases of cryptorchidism were diagnosed and 185 of these boys underwent orchiopexy.
RESULTS
No positive association between the mothers' average weekly alcohol consumption and persistent cryptorchidism was observed. Binge drinking was nonsignificantly associated with an excess risk of orchiopexy (adjusted RR = 1.4; 95% CI 0.9-2.1), but not with having a diagnosis of cryptorchidism without orchiopexy.
CONCLUSIONS
Mothers' average weekly alcohol intake was not associated with persistent cryptorchidism, but binge drinking may be a risk factor.
目的
最近发表的一项研究报告称，母亲孕期平均每周饮酒量达五杯及以上的男孩患隐睾症的风险显著增加。本研究的目的是通过评估产前酒精暴露与持续性隐睾症之间的关联来跟进这一发现。
方法
我们使用了前瞻性收集的关于5716名男孩产前暴露情况及出生时产科信息的数据，这些数据于1984年至1987年收集。在全国患者登记系统中进行的16至19年随访期间，诊断出270例隐睾症病例，其中185名男孩接受了睾丸固定术。
结果
未观察到母亲平均每周饮酒量与持续性隐睾症之间存在正相关。暴饮与睾丸固定术风险增加无显著关联（校正风险比=1.4；95%置信区间0.9 - 2.1），但与未接受睾丸固定术的隐睾症诊断无关。
结论
母亲平均每周饮酒量与持续性隐睾症无关，但暴饮可能是一个风险因素。
Zotero 插件