Swan G E, Soll M D, Gross S J
Merck Sharp and Dohme Research Laboratories, Rahway, NJ 07065.
Vet Parasitol. 1991 Nov;40(3-4):267-72. doi: 10.1016/0304-4017(91)90106-6.
Thirty-two cattle were included in a study to confirm the efficacy of ivermectin administered at 200 micrograms kg-1 against Parafilaria bovicola and to determine the time required for resolution of the lesions caused by the parasite. Four treated and four control animals were slaughtered over 2 days starting 15, 30, 50 or 70 days after treatment. The number, distribution and surface area of carcass lesions, and the weight of tissue trimmed to render the carcasses aesthetically acceptable, were recorded and parasites were recovered from subcutaneous tissues. Significantly (P less than 0.01) fewer worms were recovered from ivermectin-treated cattle slaughtered 50 or 70 days after treatment than from controls. Reductions in the mean number and surface area of lesions, and in the weight of tissue trimmed, were statistically significant (P less than 0.05) for the ivermectin-treated group slaughtered 70 days after treatment and approached significance (P less than 0.1) for the ivermectin group slaughtered 50 days after treatment.
32头牛被纳入一项研究，以确认按200微克/千克体重施用伊维菌素对牛副丝虫的疗效，并确定寄生虫引起的病变消退所需的时间。在治疗后15、30、50或70天开始的2天内，屠宰4头治疗动物和4头对照动物。记录胴体病变的数量、分布和表面积，以及为使胴体在美观上可接受而修整的组织重量，并从皮下组织中回收寄生虫。治疗后50或70天屠宰的经伊维菌素治疗的牛体内回收的蠕虫数量明显少于对照组（P<0.01）。对于治疗后70天屠宰的伊维菌素治疗组，病变的平均数量和表面积以及修整组织的重量减少具有统计学意义（P<0.05），对于治疗后50天屠宰的伊维菌素组，减少接近显著水平（P<0.1）。
