van Wyk J A, Groeneveld H T, Carmichael I H
Section of Helminthology, Veterinary Research Institute, Onderstepoort, Republic of South Africa.
Onderstepoort J Vet Res. 1990 Jun;57(2):103-8.
Parafilariosis was first described in South Africa in 1964, thereafter being discovered at numerous localities in the country. When it became obvious that Parafilaria bovicola, for which no treatment was known, caused considerable economic losses, trials involving a series of compounds were conducted to identify candidate remedies. This paper describes an anthelmintic test for evaluating the efficacy of compounds for registration for field use. Recovery of Parafilaria worms is impractical for anthelmintic testing, and consequently the lesion sizes of treated and control groups of cattle are compared statistically, using appropriate statistical tests. The seasonal incidence of mature worm infection in cattle in South Africa is such that trials should commence after June and be completed before the end of January, allowing a lapse of 70 days between treatment and slaughter for resolution of the lesions. The presently available parafilaricidal compounds while of value for treating slaughter stock, when used alone will probably not be effective for control of infection in the field.
副丝虫病于1964年在南非首次被描述，此后在该国的多个地方被发现。当很明显当时尚无治疗方法的牛副丝虫会造成相当大的经济损失时，人们进行了一系列涉及多种化合物的试验以确定候选药物。本文描述了一种驱虫试验，用于评估化合物在田间使用登记时的疗效。在驱虫试验中，要回收副丝虫是不切实际的，因此，使用适当的统计检验方法，对治疗组和对照组牛的病变大小进行统计学比较。南非牛群中成熟虫体感染的季节性发病率使得试验应在6月之后开始，并在1月底之前完成，在治疗和屠宰之间留出70天的时间以解决病变问题。目前可用的杀副丝虫化合物虽然对治疗待屠宰牲畜有价值，但单独使用时可能对控制田间感染无效。
