Rist Cassidy, Zheng Rose, Maghak Lauren
Department of Population Health Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA.
Parasitology. 2025 May;152(6):573-582. doi: 10.1017/S0031182025100280.
There is growing interest in using avermectins in livestock as a vector control tool for mosquitoes involved in the transmission of human malaria in sub-Saharan Africa (SSA). If implemented, the potential health and productivity impacts across the livestock sector would need to be considered, as avermectins are already commonly used in veterinary medicine to treat gastrointestinal helminths and parasitic insects. Here we present the results of a restricted systematic review that summarizes what is known about the effects of avermectins on cattle and swine productivity in SSA and the presence of avermectin resistance in endo- and ectoparasites of importance in these species. A total of 583 unique journal articles were identified using key search terms in 3 databases: Agriculture, Life, and Natural Sciences Databases from ProQuest, CAB Abstracts and Scopus. Ten articles met the criteria for inclusion on impacts on productivity and 4 met the inclusion criteria related to avermectin resistance. All studies documenting impacts of avermectins on productivity were performed using ivermectin in cattle. Generally, these showed a positive significant effect on growth rates. Resistance to avermectins was documented in 2 of the 4 included articles. Considering the extensive literature documenting resistance to avermectins in other areas of the world, our findings may reflect a paucity of studies on the subject in SSA. The authors conclude that additional research is needed to quantify the potential benefits and challenges to the livestock sector of using avermectins for malaria control across different production systems, and in a variety of ecological settings.
在撒哈拉以南非洲（SSA），人们越来越关注将阿维菌素用作牲畜的病媒控制工具，以控制传播人类疟疾的蚊子。如果实施这一做法，就需要考虑对整个畜牧业可能产生的健康和生产力影响，因为阿维菌素已普遍用于兽医学中治疗胃肠道蠕虫和寄生虫。在此，我们展示了一项受限系统评价的结果，该评价总结了关于阿维菌素对SSA地区牛和猪生产力的影响以及这些物种体内外重要寄生虫对阿维菌素耐药性的已知情况。使用来自ProQuest的农业、生命和自然科学数据库、CAB文摘数据库和Scopus这3个数据库中的关键检索词，共识别出583篇独特的期刊文章。10篇文章符合关于生产力影响的纳入标准，4篇符合与阿维菌素耐药性相关的纳入标准。所有记录阿维菌素对生产力影响的研究均使用伊维菌素对牛进行。总体而言，这些研究表明对生长速率有显著的积极影响。在纳入的4篇文章中有2篇记录了对阿维菌素的耐药性。考虑到世界其他地区有大量记录阿维菌素耐药性的文献，我们的研究结果可能反映出SSA地区在该主题上的研究较少。作者得出结论，需要开展更多研究，以量化在不同生产系统和各种生态环境中使用阿维菌素控制疟疾对畜牧业的潜在益处和挑战。
