从栀子中提取藏红花素衍生物时，萃取与膨胀床吸附的直接工艺集成。

Direct process integration of extraction and expanded bed adsorption in the recovery of crocetin derivatives from Fructus Gardenia.

作者信息

Zhang Min, Hu Ping, Liang Qionglin, Yang Huihua, Liu Qingfei, Wang Yiming, Luo Guoan

机构信息

Modern Engineering Center for Traditional Chinese Medicine, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.

出版信息

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Oct 15;858(1-2):220-6. doi: 10.1016/j.jchromb.2007.08.041. Epub 2007 Sep 6.

DOI:10.1016/j.jchromb.2007.08.041

PMID:17890164

Abstract

A process that integrated an extraction tank (EXT) and an expanded bed adsorption (EBA) into a new system EXT-EBA for direct purifying crocetin derivatives from Fructus Gardenia was described. Conditions were set to allow the extraction and purification in a single step. A comparison between the integrated process and the conventional process to purify crocetin derivatives was presented. The integrated process resulted in 52.79% recovery of crocin compared to 24.12% in the conventional process. The process time and solvent used were decreased in the integrated process. The result suggests that the EXT-EBA integrates extraction, clarification, and purification in a single step, greatly simplifying the process flow and reducing the cost and time of extraction and purification of crocetin derivatives from Fructus Gardenia.

摘要

描述了一种将萃取罐（EXT）和扩张床吸附（EBA）集成到一个新系统EXT-EBA中的过程，用于直接从栀子中纯化西红花酸衍生物。设定条件以实现一步法萃取和纯化。对纯化西红花酸衍生物的集成工艺与传统工艺进行了比较。集成工艺中藏红花素的回收率为52.79%，而传统工艺为24.12%。集成工艺减少了工艺时间和溶剂用量。结果表明，EXT-EBA一步法集成了萃取、澄清和纯化，大大简化了工艺流程，降低了从栀子中提取和纯化西红花酸衍生物的成本和时间。