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一条导致稳定期基因表达噪声升高的途径和遗传因素。

A pathway and genetic factors contributing to elevated gene expression noise in stationary phase.

作者信息

Guido Nicholas J, Lee Philina, Wang Xiao, Elston Timothy C, Collins J J

机构信息

Department of Biomedical Engineering and Center for BioDynamics, Boston University, Boston, Massachusetts, USA.

出版信息

Biophys J. 2007 Dec 1;93(11):L55-7. doi: 10.1529/biophysj.107.118687. Epub 2007 Sep 21.

DOI:10.1529/biophysj.107.118687
PMID:17890398
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2084246/
Abstract

Previous studies have identified factors associated with transcription and translation efficiency, such as promoter strength and mRNA sequences, that can affect stochasticity in gene expression. Here we present evidence for a pathway and associated genetic factors (namely, the ribosome modulation factor RMF and ppGpp) in Escherichia coli that contribute to heightened levels of gene expression noise during stationary phase. Endogenous cellular mechanisms that globally affect gene expression noise, such as those identified in this study, could provide phenotypic diversity under adverse conditions such as stationary phase.

摘要

先前的研究已经确定了与转录和翻译效率相关的因素，如启动子强度和mRNA序列，这些因素会影响基因表达的随机性。在这里，我们提供了大肠杆菌中一条途径及相关遗传因素（即核糖体调节因子RMF和ppGpp）的证据，这些因素在稳定期会导致基因表达噪声水平升高。像本研究中所确定的那些全局影响基因表达噪声的内源性细胞机制，可能在诸如稳定期这样的不利条件下提供表型多样性。

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